HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Johnson, E. W. Articles by Innis, R. B. Search for Related Content PubMed PubMed Citation Articles by Johnson, E. W. Articles by Innis, R. B.

"Central" and "peripheral" benzodiazepine receptors

Opposite changes in human epileptogenic tissue

Departments of Psychiatry, Neurology, and Diagnostic Radiology and Section of Neurological Surgery, Yale University School of Medicine and West Haven Veterans Affairs Medical Center, West Haven, CT.

We measured the density of two benzodiazepine (BZ) receptor subtypes in neurosurgically obtained hippocampal tissue from the seizure focus of patients with temporal lobe epilepsy (TLE) showing mesial temporal sclerosis, the most common pathologic finding in TLE. We performed quantitative in vitro receptor autoradiography with [¹²⁵I]Ro 16–0154, a probe for the central-type BZ receptor and with [³H]PK 11195, a probe for the peripheral-type BZ receptor. In comparison with autopsy and neurosurgical control groups, patients with mesial temporal sclerosis had regionally selective decreased central-type and increased peripheral-type BZ receptors. These changes paralleled regional losses of neurons and proliferation of glia. Decreases of the inhibitory central-type BZ receptor may be a component of the enhanced excitability of the seizure focus and also may allow localization of the focus by in vivo neurore-ceptor imaging. Single photon emission computed tomography (SPECT) imaging of two TLE patients with [¹²³I]Ro 16–0154 suggests that this technique may provide a more sensitive means of localizing the seizure focus than current imaging methods relying on changes in blood flow or glucose metabolism.

Address correspondence and reprint requests to Dr. Robert B. Innis, Psychiatry Service/116A2, West Haven VA Medical Center, 950 Campbell Ave, West Haven, CT 06516.

Supported by funds from the Department of Veterans Affairs (Merit Review Award to R.B.I. and the National Center for Post-Traumatic Stress Disorder) and from NINDS (NS06208).

Received June 12, 1991. Accepted for publication in final form September 10, 1991.

This article has been cited by other articles:

				Y F Tai and P Piccini Applications of positron emission tomography (PET) in neurology J. Neurol. Neurosurg. Psychiatry, May 1, 2004; 75(5): 669 - 676. [Abstract] [Full Text] [PDF]

				F. Loup, H.-G. Wieser, Y. Yonekawa, A. Aguzzi, and J.-M. Fritschy Selective Alterations in GABAA Receptor Subtypes in Human Temporal Lobe Epilepsy J. Neurosci., July 15, 2000; 20(14): 5401 - 5419. [Abstract] [Full Text] [PDF]

				S. Lamusuo, A. Pitkanen, L. Jutila, A. Ylinen, K. Partanen, R. Kalviainen, H.-M. Ruottinen, V. Oikonen, K. Nagren, P. Lehikoinen, et al. [11C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology Neurology, June 27, 2000; 54(12): 2252 - 2260. [Abstract] [Full Text] [PDF]

				J. W. Gibbs III, S. Sombati, R. J. Delorenzo, and D. A. Coulter Physiological and Pharmacological Alterations in Postsynaptic GABAA Receptor Function in a Hippocampal Culture Model of Chronic Spontaneous Seizures J Neurophysiol, April 1, 1997; 77(4): 2139 - 2152. [Abstract] [Full Text] [PDF]

				A. S. Harvey and S. F. Berkovic Functional Neuroimaging With SPECT in Children With Partial Epilepsy J Child Neurol, October 1, 1994; 9(1_suppl): S71 - S81. [Abstract] [PDF]