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Accelerated aging of the brain in Werner's syndrome

Department of Internal Medicine, Saga Medical School, Nabeshima, Saga, Japan.

We report the electrophysiologic examination of a 55-year-old woman with Werner's syndrome. Needle EMG and peripheral conduction studies were normal. In contrast, EEG was moderately abnormal, the N20 and P25 potentials of SEPs were delayed and enlarged, and the event-related potential, P300, was delayed. These characteristic findings indicated accelerated aging of the brain, as in the other organs, in Werner's syndrome.

Address correspondence and reprint requests to Dr. Ryusuke Kakigi, Department of Internal Medicine, Saga Medical School, Nabeshima, Saga, 849, Japan.

Supported by the Brain Science Foundation, by Kato Memorial Trust for Nambyou Research in Japan, by The Long Life Science General Product from the Ministry of Health and Welfare of Japan, and by grants no. 02857123 and 03807049 and Grant-in-Aid for New Program "Investigative Studies on Physiological Functions" (No. 03NP0101) from the Ministry of Education, Science and Culture of Japan.

Received August 16. 1991. Accepted for publication in final form September 25, 1991.