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NEUROLOGY 1992;42:1037
© 1992 American Academy of Neurology

Ocular motor function in motor neuron disease

Martin Gizzi, MD, PhD, Alessandro DiRocco, MD, Mark Sivak, MD and Bernard Cohen, MD

From the Department of Neurology, Mount Sinai School of Medicine, New York, NY.

We studied ocular motor function in 34 patients with motor neuron disease (MND) and in 18 age matched controls. This included the latency, accuracy, and amplitude-velocity relationships of saccades. We also examined ocular pursuit, the slow phases of optokinetic nystagmus, and the ability to suppress the vestibulo-ocular reflex (VOR) with visual fixation of' a head-mounted target. Five of the subjects with MND had pronounced parkinsonian features on neurologic examination. The nonparkinsonian MND subjects had normal ocular motor function for all measures. Most subjects suppressed the VOR completely. The parkinsonian-MND patients had impairment of both saccadic and pursuit eye movements, and one parkinsonian-MND patient with poor pursuit was unable to suppress the VOR. We conclude that ocular motor function is generally spared in MND. The occasional appearance of ocular motor dysfunction probably reflects the incidence of secondary abnormalities such as parkinsonism.

Address correspondence and reprint requests to Dr. Martin Gizzi, Box 1052. Mount Sinai Hospital, 1 Gustave L. Levy Place, New York, NY 10029.

Supported by a grant from the National Eye Institute (EY003061).

Presented in part at the 43rd annual meeting of the American Academy of Neurology, Boston, MA, April 1991.

Received July 23, 1991. Accepted for publication in final form October 31, 1991.






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