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Comparison of cisternal and lumbar CSF examination in leptomeningeal metastasis

Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH. (Dr. Rogers)
Department of Radiology, The Cleveland Clinic Foundation, Cleveland, OH. (Dr. Duchesneau)
Department of Pathology, The Cleveland Clinic Foundation, Cleveland, OH. (Dr. Nunez)
Department of Laboratory Hematology, The Cleveland Clinic Foundation, Cleveland, OH. (Dr. Fishleder)
Department of Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH. (Dr. Weick)
Departments of Biostatistics and Epidemiology, The Cleveland Clinic Foundation, Cleveland, OH. (L.J. Bauer and Dr. Boyett)

We compared cisternal and lumbar CSF examination in 14 patients suspected of having leptomeningeal metastasis from cancer. Malignant cells were present in 12 patients—in both cisternal and lumbar CSF in nine patients and only in cisternal CSF in three. Cisternal CSF cytologie examination should be considered in patients suspected of having leptomeningeal metastasis if lumbar CSF is nondiagnostic.

Address correspondence and reprint requests to Dr. Lisa R. Rogers, Neuro-oncology Program, Department of Neurology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195.

Received June 26, 1991. Accepted for publication in final form November 12, 1991.

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