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From the Department of Neurosciences (Drs. Langlais, Thal, Hansen, Galasko, and Masliah, and M. Alford), University of California at San Diego, School of Medicine; the Neurology Research Service (Drs. Langlais, Thai, and Galasko), Veterans Affairs Medical Center; and the Department of Psychology (Dr. Langlais), San Diego State University, San Diego, CA.
We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Lewy body variant [LBV]), and normal controls. Dopamine and homovanillic acid (HVA) were severely depleted in basal ganglia of the LBV cases but were not significantly altered in pure AD cases; tyrosine hydroxylase levels in putamen were also significantly reduced in LBV but not AD cases. These reductions in basal ganglia dopamine and HVA suggest that LBV cases have a level of dopamine depletion similar to Parkinson's disease (PD). Additionally, ChAT activity in caudate and norepinephrine concentration in putamen were significantly reduced in the LBV group, which may have contributed to the absence of resting tremor and the milder presentation of parkinsonian features in this group compared with classic PD. In frontal, parietal, and temporal cortex, activity of ChAT in the LBV group was significantly reduced compared with controls and lower than in pure AD.
Address correspondence and reprint requests to Dr. Philip Langlais, Neurology Research Service (127), VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161.
Supported by funds from the VA Merit Review Program, NIH/DRR grants S10 RRO 4654-01 and AG05131, and PHS grant MH NS 31862 to the Brain Tissue Resource Center.
Received November 24,1992. Accepted for publication in final form March 8, 1993
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