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NEUROLOGY 1993;43:2006
© 1993 American Academy of Neurology

Measurement of whole temporal lobe and hippocampus for MR volumetry

Normative data

Sanjiv Bhatia, MD, Susan Y. Bookheimer, PhD, William D. Gaillard, MD and William H. Theodore, MD

From the Epilepsy Research Branch, National Institutes of Health, Bethesda, MD.

We measured the volumes of the entire length of temporal lobe and hippocampal formation from coronal images in 29 healthy young adults to take into account normal side-to-side variation. Although whole-brain, temporal lobe, and left hippocampal volumes were significantly smaller in women, normalizing measurements for the whole brain eliminated intersex temporal lobe and hippocampal differences. There was a weak but significant inverse correlation between age and normalized hippocampal, but not temporal lobe or whole-brain, volume. In contrast to previous studies, we found no significant side-to-side differences in the sizes of temporal lobes or hippocampi. When performing MR volumetry, it is important to include the entire length of the hippocampal formation.

Address correspondence and reprint requests to Dr. William Theodore, Epilepsy Research Branch, Building 10, Room 5C 207, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892.

Received November 2, 1992. Accepted for publication in final form March 3, 1993.




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