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Sensory neuropathy associated with Dursban (chlorpyrifos) exposure

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.

Chlorpyrifos (Dursban) is an organophosphate insecticide with extensive domestic and agricultural applications. It is regarded as safe for these purposes; one report of neurotoxicity is attributed to massive ingestion in a suicide attempt. We report eight people who developed peripheral neuropathy after exposure to exterminator-applied commercial Dursban; five also experienced memory loss and cognitive slowing. Evaluation failed to reveal other causes of neurologic dysfunction; symptoms recurred in one patient following accidental reexposure. We conclude that environmental contact with chlorpyrifos can cause sensory neuropathy and CNS dysfunction and that this agent should be used with caution.

Address correspondence and reprint requests to Dr. Jerry G. Kaplan, Montefiore Medical Park, Department of Neurology, 1575 Blondell Avenue, Suite 225, Bronx, NY 10461.

*Deceased.

Received September 29, 1992. Accepted for publication in final form April 20, 1993.

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