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Departments of Neurology (Dr Mendez and A Selwood), Neuropathology (Dr Mastri), and Psychiatry (Dr Frey), St Paul-Ramsey Medical Center and the University of Minnesota, St. Paul, MN. Dr Mastri is now with the Chief Medical Examiner, City of New York, NY.
The clinical recognition of Pick's disease depends on its differentiation from Alzheimer's disease (AD). To identify distinguishing clinical features, we reviewed the clinical records of 21 patients with pathologically confirmed Pick's disease and matched them by sex, age of onset, and duration of dementia with 42 patients having pathologically confirmed AD. In the absence of temporal or frontal lobar atrophy on CTs, all the Pick patients and none of the AD patients had three of five clinical features: presenile onset (before age 66), an initial personality change, hyperorality, disinhibition, and roaming behavior. In addition, the Pick patients had a tendency toward reiterative and other speech disturbances. These findings suggest that Pick patients are potentially distinguishable from AD patients on the basis of clinical manifestations.
Address correspondence and reprint requests to Dr. Mario F Mendez, Department of Neurology, St. Paul-Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101
The Alzheimer's Treatment and Research Center Brain Bank is supported by grants from the State of Minnesota, 3M Foundation, Robert Wood Johnson, Jr., Charitable Trust, and the Ramsey Foundation.
Presented in part at the 44th annual meeting of the American Academy of Neurology, San Diego. CA, May 1992.
Received April 21, 1992 Accepted for publication in final form June 16, 1992.
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