| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neurology Service (Drs. Levine and Fisher) and the C.S. Kubik Laboratory of Neuropathology (Dr. Lee), Massachusetts General Hospital, Boston; and the Departments of Neurology and Pathology, Harvard Medical School, Boston, MA.
A 59-year-old man developed problems with reading and driving. When first examined, he had great difficulty locating and identifying items by sight. Visual acuity was normal, but contrast sensitivity for low spatial frequencies was severely impaired. The peripheral visual fields were moderately constricted with depressed flicker fusion frequencies, more on the right. Color identification was preserved. The difficulties in identifying and locating objects by sight were aggravated by increasing the complexity and multiplicity of the items in the field of vision and by changing the ambient illumination. Intellect and memory were relatively intact, except for difficulty with calculations. Over a 12-year course the visual defects steadily worsened, and eventually memory and language skills failed. Social manners, perseverance, and affect remained normal. Postmortem examination showed cortical atrophy, predominantly posterior, with abundant neurofibrillary tangles and senile plaques. The density of the tangles was correlated with the severity of the atrophy, being highest in the occipitoparietal areas and lowest in the frontal lobes. Alzheimer's disease can preferentially affect the posterior cerebral hemispheres and cause a dementia presenting with, and dominated by, visual disturbances.
Address correspondence and reprint requests to Dr. David N. Levine, New York University Medical Center, Rusk Institute, Room 220, 400 East 34 Street, New York, NY 10016.
Received April 23, 1992. Accepted for publication in final form July 1, 1992.
This article has been cited by other articles:
|
|
 |
|
  K. Wiesehan, J. Stohr, L. Nagel-Steger, T. van Groen, D. Riesner, and D. Willbold Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide Protein Eng. Des. Sel., April 1, 2008; 21(4): 241 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Decker Measuring Growth and Decline in Visual-Motor Processes With the Bender-Gestalt Second Edition Journal of Psychoeducational Assessment, March 1, 2008; 26(1): 3 - 15. [Abstract] [PDF]
|
|
|
|
 |
|
 K. A. Josephs, J. L. Whitwell, B. F. Boeve, D. S. Knopman, D. F. Tang-Wai, D. A. Drubach, C. R. Jack Jr, and R. C. Petersen Visual hallucinations in posterior cortical atrophy. Arch Neurol, October 1, 2006; 63(10): 1427 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Tang-Wai and M. Mapstone What are we seeing?: Is posterior cortical atrophy just Alzheimer disease? Neurology, February 14, 2006; 66(3): 300 - 301. [Full Text] [PDF]
|
|
|
|
|
|
S. Ataka, T. Tomiyama, H. Takuma, T. Yamashita, H. Shimada, T. Tsutada, K. Kawabata, H. Mori, and T. Miki A Novel Presenilin-1 Mutation (Leu85Pro) in Early-Onset Alzheimer Disease With Spastic Paraparesis Arch Neurol, November 1, 2004; 61(11): 1773 - 1776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Tang-Wai, N. R. Graff-Radford, B. F. Boeve, D. W. Dickson, J. E. Parisi, R. Crook, R. J. Caselli, D. S. Knopman, and R. C. Petersen Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy Neurology, October 12, 2004; 63(7): 1168 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Renner, J. M. Burns, C. E. Hou, D. W. McKeel Jr., M. Storandt, and J. C. Morris Progressive posterior cortical dysfunction: A clinicopathologic series Neurology, October 12, 2004; 63(7): 1175 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P J Nestor, D Caine, T D Fryer, J Clarke, and J R Hodges The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET J. Neurol. Neurosurg. Psychiatry, November 1, 2003; 74(11): 1521 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lambon Ralph, K. Patterson, N. Graham, K. Dawson, and J. R. Hodges Homogeneity and heterogeneity in mild cognitive impairment and Alzheimer's disease: a cross-sectional and longitudinal study of 55 cases Brain, November 1, 2003; 126(11): 2350 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Knopman, B. F. Boeve, and R. C. Petersen Essentials of the Proper Diagnoses of Mild Cognitive Impairment, Dementia, and Major Subtypes of Dementia Mayo Clin. Proc., October 1, 2003; 78(10): 1290 - 1308. [Abstract] [PDF]
|
|
|
|
 |
|
 R. W. Crow, L. B. Levin, L. LaBree, R. Rubin, and S. E. Feldon Sweep Visual Evoked Potential Evaluation of Contrast Sensitivity in Alzheimer's Dementia Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 875 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. W. Bokde, P. Pietrini, V. Ibanez, M. L. Furey, G. E. Alexander, N. R. Graff-Radford, S. I. Rapoport, M. B. Schapiro, and B. Horwitz The Effect of Brain Atrophy on Cerebral Hypometabolism in the Visual Variant of Alzheimer Disease Arch Neurol, March 1, 2001; 58(3): 480 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N A Thacker and A Jackson Mathematical segmentation of grey matter, white matter and cerebral spinal fluid from MR image pairs Br. J. Radiol., March 1, 2001; 74(879): 234 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Galton, K. Patterson, J. H. Xuereb, and J. R. Hodges Atypical and typical presentations of Alzheimer's disease: a clinical, neuropsychological, neuroimaging and pathological study of 13 cases Brain, March 1, 2000; 123(3): 484 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Johnson, E. Head, R. Kim, A. Starr, and C. W. Cotman Clinical and Pathological Evidence for a Frontal Variant of Alzheimer Disease Arch Neurol, October 1, 1999; 56(10): 1233 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Teipel, H. Hampel, P. Pietrini, G. E. Alexander, B. Horwitz, E. Daley, H.-J. Moller, M. B. Schapiro, and S. I. Rapoport Region-Specific Corpus Callosum Atrophy Correlates With the Regional Pattern of Cortical Glucose Metabolism in Alzheimer Disease Arch Neurol, April 1, 1999; 56(4): 467 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Perry and J. R. Hodges Attention and executive deficits in Alzheimer's disease: A critical review Brain, March 1, 1999; 122(3): 383 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bashir, R. J. Elble, M. Ghobrial, and R. G. Struble Hemianopsia in Dementia With Lewy Bodies Arch Neurol, August 1, 1998; 55(8): 1132 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Ala, W. H. Frey II, and H. B. Clark Posterior Cortical Atrophy: Neuropathological Correlations Arch Neurol, October 1, 1996; 53(10): 958 - 958. [Abstract] [PDF]
|
|
|
|
|
|
J. D. W. Greene, K. Patterson, J. Xuereb, and J. R. Hodges Alzheimer Disease and Nonfluent Progressive Aphasia Arch Neurol, October 1, 1996; 53(10): 1072 - 1078. [Abstract] [PDF]
|
|
|
|
|
|
J. Victoroff, G. W. Ross, D. F. Benson, M. A. Verity, and H. V. Vinters Posterior Cortical Atrophy: Neuropathologic Correlations Arch Neurol, March 1, 1994; 51(3): 269 - 274. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
