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NEUROLOGY 1993;43:333
© 1993 American Academy of Neurology

Intramedullary spinal sarcoidosis

Clinical and magnetic resonance imaging characteristics

S. S. Junger, MD, B. J. Stern, MD, S. R. Levine, MD, E. Sipos, MD and J. F. Marti-Masso, MD

North Central Neurology (Dr. Junger), Denville, NJ; Division of Neurology (Dr. Stern), Sinai Hospital of Baltimore, and Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD; Department of Neurology (Dr. Levine), Henry Ford Hospital, Detroit, MI; Department of Neurology (Dr. Marti-Masso), Hospital Nuestra Sra de Aranazazu, San Sebastian, Spain; and Department of Surgery (Dr. Sipos), The Johns Hopkins Medical Institutions, Baltimore, MD.

We present a retrospective series of the clinical and MRI findings in 16 patients with intramedullary spinal sarcoidosis (ISS), including 12 patients studied with gadolinium-DTPA. The spectrum of MRI findings includes leptomeningeal enhancement, fusiform spinal cord enlargement, focal or diffuse intramedullary disease, and spinal cord atrophy. We present a classification of ISS correlating the clinical progression and the temporal sequence of MRI abnormalities. Improvement occurred in five of 12 patients (42%) treated with immunosuppressive therapy.

Address correspondence and reprint requests to Dr. Sylvain S. Junger, North Central Neurology, 94 Diamond Spring Road, Denville, NJ 07834.

Presented in part at the 41st annual meeting of the American Academy of Neurology, Chicago, IL, April 1989.

Received November 6, 1991. Accepted for publication in final form June 25, 1992.




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