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Sulfated glucuronyl glycolipids and gangliosides in the optic nerve of humans

Department of Biochemistry and Molecular Biophysics (Drs. Yoshino, Maeda, Ariga. and Yu), and the Department of' Ophthalmology (Drs. King, Cartwright, and Richards), Medical College of Virginia, Virginia Commonwealth University, Richmond, VA.

Pathologically delayed visual evoked potentials may be present in patients with neuropathy associated with IgM M-proteinemia, which is directed against myelin-associated glycoprotein and sulfated glucuronyl glycolipids (SGGLs), but there are no reports of these antigens in the optic nerve. We recently examined human optic nerve and occipital lobe tissues for the occurrence of SGGLs using the technique of immunostaining on thin-layer chromato-graphic plates and found them in the optic nerve, but not the occipital lobe. SGGLs in the optic nerve may represent target antigens for CNS involvement by the M-protein in patients with neuropathy. We also studied the ganglioside composition of the optic nerve and found it different from that of the brain. Human optic nerve is characterized by an abundance of the b-series gangliosides, including GDlb, GTlb, and GQlb. GDla, which is usually a major component of brain gangliosides, is only a minor species of the optic nerve ganglioside fraction.

Address correspondence and reprint requests to Dr. R.K. Yu, Department of Biochemistry and Molecular Biophysics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298–0614.

Supported by USPHS grants NS-23102, NS-26994, and AD Williams Committee Grant 6–46878.

Received May 27. 1992. Accepted for publication in final form July 1, 1992.

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