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NEUROLOGY 1993;43:544
© 1993 American Academy of Neurology

Low-dose apomorphine challenge in tardive akathisia

Perminder Sachdev, MD, PhD, FRANZCP and Celia Loneragan, MA

Neuropsychiatric Institute, The Prince Henry Hospital, Sydney, Australia.

We challenged seven tardive akathisia patients with low-dose apomorphine (0.01 mg/kg) SC and placebo in a double-blind, random design. Apomorphine caused a significantly greater reduction in the objective (movement) but not the subjective (distress) component of akathisia.

Address correspondence and reprint requests to Dr. Perminder Sachdev, P.O. Box 233, Matraville NSW 2036, Australia.

Supported in part by the National Health and Medical Research Council of Australia and by the Rebecca Cooper and Ramaciotti Foundations.

Received June 1, 1992. Accepted for publication in final form July 31, 1992.






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