Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singer, H. S.
Right arrow Articles by Denckla, M. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singer, H. S.
Right arrow Articles by Denckla, M. B.
NEUROLOGY 1993;43:950
© 1993 American Academy of Neurology

Volumetric MRI changes in basal ganglia of children with Tourette's syndrome

H. S. Singer, MD, A. L. Reiss, MD, J. E. Brown, RN, E. H. Aylward, PhD, B. Shih, BA, E. Chee, ScD, E. L. Harris, PhD, M. J. Reader, PhD, G. A. Chase, PhD, R. N. Bryan, MD and M. B. Denckla, MD

Departments of Neurology, Pediatrics, Psychiatry, Radiology, and Epidemiology, Johns Hopkins University School of Medicine, School of Hygiene and Public Health, and the Kennedy Kreiger Institute, Baltimore, MD.

To define the site of pathology in Tourette's syndrome (TS), we performed a volumetric MRI study of basal ganglia structures and lateral ventricles on 37 children with this disorder and 18 controls. There were no statistically significant differences in the size of the right or left caudate, putamen, globus pallidus, or ventricles in these populations. In contrast, there were significant differences for measures of symmetry in the putamen and the lenticular region. Virtually all controls (17 right- and one left-handed) had a left-sided predominance of the putamen, whereas in 13 of 37 TS subjects, a right predominance exceeded that of any control. Statistical comparisons among TS patients, with (n = 18) or without (n = 19) attention-deficit hyperactivity disorder (ADHD), and controls showed significant differences for the volume of the left globus pallidus and for lenticular asymmetry. Post hoc evaluations showed that in the TS + ADHD group, the volume of the left globus pallidus was significantly smaller than the volume of the right and that lenticular asymmetry was due to a greater right-sided predominance in the TS + ADHD group. This study lends further support to proposals that claim the basal ganglia is involved in the pathogenesis of TS and also suggests that the comorbid problem of ADHD is related to regional changes that differ from those primarily associated with tics.

Address correspondence and reprint requests to Dr. Harvey S. Singer, Department of Neurology-Harvey 811, Johns Hopkins Hospital 600 N Wolfe Street, Baltimore, MD 21287.

Supported in part by a grant from the US Public Health Service (HD 25806).

Received August 19, 1992. Accepted for publication in final form November 10, 1992.




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P Zhuang, M Hallett, X Zhang, J Li, Y Zhang, and Y Li
Neuronal activity in the globus pallidus internus in patients with tics
J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1075 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
M. I. Makki, R. Munian Govindan, B. J. Wilson, M. E. Behen, and H. T. Chugani
Altered Fronto-Striato-Thalamic Connectivity in Children with Tourette Syndrome Assessed with Diffusion Tensor MRI and Probabilistic Fiber Tracking
J Child Neurol, June 1, 2009; 24(6): 669 - 678.
[Abstract] [PDF]

Home page
 BrainHome page
G. Thomalla, H. R. Siebner, M. Jonas, T. Baumer, K. Biermann-Ruben, F. Hummel, C. Gerloff, K. Muller-Vahl, A. Schnitzler, M. Orth, et al.
Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome
Brain, March 1, 2009; 132(3): 765 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. Qiu, D. Crocetti, M. Adler, E. M. Mahone, M. B. Denckla, M. I. Miller, and S. H. Mostofsky
Basal Ganglia Volume and Shape in Children With Attention Deficit Hyperactivity Disorder
Am J Psychiatry, January 1, 2009; 166(1): 74 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
S. R. Chamberlain, L. A. Menzies, N. A. Fineberg, N. del Campo, J. Suckling, K. Craig, U. Muller, T. W. Robbins, E. T. Bullmore, and B. J. Sahakian
Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
The British Journal of Psychiatry, September 1, 2008; 193(3): 216 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
J. M. Ford, J. H. Krystal, and D. H. Mathalon
Neural Synchrony in Schizophrenia: From Networks to New Treatments
Schizophr Bull, July 1, 2007; 33(4): 848 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
P. Pavone, E. Parano, R. Rizzo, and R. R. Trifiletti
Topical Review: Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Sydenham Chorea, PANDAS, and PANDAS Variants
J Child Neurol, September 1, 2006; 21(9): 727 - 736.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
K. A. Frey and R. L. Albin
Neuroimaging of Tourette Syndrome
J Child Neurol, August 1, 2006; 21(8): 672 - 677.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
K. Harris and H. S. Singer
Tic Disorders: Neural Circuits, Neurochemistry, and Neuroimmunology
J Child Neurol, August 1, 2006; 21(8): 678 - 689.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
M. B. Denckla
Attention-Deficit Hyperactivity Disorder (ADHD) Comorbidity: A Case for ``Pure'' Tourette Syndrome?
J Child Neurol, August 1, 2006; 21(8): 701 - 703.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
J. S. Neimat, P. G. Patil, and A. M. Lozano
Novel Surgical Therapies for Tourette Syndrome
J Child Neurol, August 1, 2006; 21(8): 715 - 718.
[Abstract] [PDF]

Home page
 BrainHome page
D. J. Serrien, M. Orth, A. H. Evans, A. J. Lees, and P. Brown
Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherence
Brain, January 1, 2005; 128(1): 116 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
J S Stern, S Burza, and M M Robertson
Gilles de la Tourette's syndrome and its impact in the UK
Postgrad. Med. J., January 1, 2005; 81(951): 12 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
K. J. Plessen, T. Wentzel-Larsen, K. Hugdahl, P. Feineigle, J. Klein, L. H. Staib, J. F. Leckman, R. Bansal, and B. S. Peterson
Altered Interhemispheric Connectivity in Individuals With Tourette's Disorder
Am J Psychiatry, November 1, 2004; 161(11): 2028 - 2037.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
C. Francois, D. Grabli, K. McCairn, C. Jan, C. Karachi, E.-C. Hirsch, J. Feger, and L. Tremblay
Behavioural disorders induced by external globus pallidus dysfunction in primates II. Anatomical study
Brain, September 1, 2004; 127(9): 2055 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R.L. Albin, R.A. Koeppe, N.I. Bohnen, T.E. Nichols, P. Meyer, K. Wernette, S. Minoshima, M.R. Kilbourn, and K.A. Frey
Increased ventral striatal monoaminergic innervation in Tourette syndrome
Neurology, August 12, 2003; 61(3): 310 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
B. S. Peterson, P. Thomas, M. J. Kane, L. Scahill, H. Zhang, R. Bronen, R. A. King, J. F. Leckman, and L. Staib
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Arch Gen Psychiatry, April 1, 2003; 60(4): 415 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
H. S. Singer, S. Szymanski, J. Giuliano, F. Yokoi, A. S. Dogan, J. R. Brasic, Y. Zhou, A. A. Grace, and D. F. Wong
Elevated Intrasynaptic Dopamine Release in Tourette's Syndrome Measured by PET
Am J Psychiatry, August 1, 2002; 159(8): 1329 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. J. Serrien, A. C. Nirkko, T. J. Loher, K.-O. Lovblad, J.-M. Burgunder, and M. Wiesendanger
Movement control of manipulative tasks in patients with Gilles de la Tourette syndrome
Brain, February 1, 2002; 125(2): 290 - 300.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K.A. Fredericksen, L.E. Cutting, W.R. Kates, S.H. Mostofsky, H.S. Singer, K.L. Cooper, D.C. Lanham, M.B. Denckla, and W.E. Kaufmann
Disproportionate increases of white matter in right frontal lobe in Tourette syndrome
Neurology, January 8, 2002; 58(1): 85 - 89.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. Kurlan, M. P. McDermott, C. Deeley, P. G. Como, C. Brower, S. Eapen, E. M. Andresen, and B. Miller
Prevalence of tics in schoolchildren and association with placement in special education
Neurology, October 23, 2001; 57(8): 1383 - 1388.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. L. LeVasseur, J. R. Flanagan, R. J. Riopelle, and D. P. Munoz
Control of volitional and reflexive saccades in Tourette's syndrome
Brain, October 1, 2001; 124(10): 2045 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. D. Rosas, J. Goodman, Y. I. Chen, B. G. Jenkins, D. N. Kennedy, N. Makris, M. Patti, L. J. Seidman, M. F. Beal, and W. J. Koroshetz
Striatal volume loss in HD as measured by MRI and the influence of CAG repeat
Neurology, September 25, 2001; 57(6): 1025 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T B Babel, P C Warnke, and C B Ostertag
Immediate and long term outcome after infrathalamic and thalamic lesioning for intractable Tourette's syndrome
J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 666 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
B. S. Peterson, L. Staib, L. Scahill, H. Zhang, C. Anderson, J. F. Leckman, D. J. Cohen, J. C. Gore, J. Albert, and R. Webster
Regional Brain and Ventricular Volumes in Tourette Syndrome
Arch Gen Psychiatry, May 1, 2001; 58(5): 427 - 440.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
E. Stern, D. A. Silbersweig, K.-Y. Chee, A. Holmes, M. M. Robertson, M. Trimble, C. D. Frith, R. S. J. Frackowiak, and R. J. Dolan
A Functional Neuroanatomy of Tics in Tourette Syndrome
Arch Gen Psychiatry, August 1, 2000; 57(8): 741 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
C. H. Kwak, P. A. Hanna, and J. Jankovic
Botulinum Toxin in the Treatment of Tics
Arch Neurol, August 1, 2000; 57(8): 1190 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. M. Zimmerman, M. T. Abrams, J. D. Giuliano, M. B. Denckla, and H. S. Singer
Subcortical volumes in girls with Tourette syndrome: Support for a gender effect
Neurology, June 27, 2000; 54(12): 2224 - 2229.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
B. S. Peterson, J. F. Leckman, D. Tucker, L. Scahill, L. Staib, H. Zhang, R. King, D. J. Cohen, J. C. Gore, and P. Lombroso
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders
Arch Gen Psychiatry, April 1, 2000; 57(4): 364 - 372.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. H. Mostofsky, J. Wendlandt, L. Cutting, M. B. Denckla, and H. S. Singer
Corpus callosum measurements in girls with Tourette syndrome
Neurology, October 1, 1999; 53(6): 1345 - 1345.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
Y. Awaad
Tics in Tourette Syndrome: New Treatment Options
J Child Neurol, May 1, 1999; 14(5): 316 - 319.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
L. A. O'Tuama, D. P. Dickstein, R. Neeper, and G. G. Gascon
Topical Review: Functional Brain Imaging in Neuropsychiatric Disorders of Childhood
J Child Neurol, April 1, 1999; 14(4): 207 - 221.
[Abstract] [PDF]

Home page
 Am. J. PsychiatryHome page
R. Bartha, M. B. Stein, P. C. Williamson, D. J. Drost, R. W.J. Neufeld, T. J. Carr, G. Canaran, M. Densmore, G. Anderson, and A. R. Siddiqui
A Short Echo 1H Spectroscopy and Volumetric MRI Study of the Corpus Striatum in Patients With Obsessive- Compulsive Disorder and Comparison Subjects
Am J Psychiatry, November 1, 1998; 155(11): 1584 - 1591.
[Abstract] [Full Text]

Home page
 J Child NeurolHome page
S. H. Mostofsky, A. L. Reiss, P. Lockhart, and M. B. Denckla
Evaluation of Cerebellar Size in Attention-Deficit Hyperactivity Disorder
J Child Neurol, September 1, 1998; 13(9): 434 - 439.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
L. J. Schuerholz, H. S. Singer, and M. B. Denckla
Gender Study of Neuropsychological and Neuromotor Function in Children With Tourette Syndrome With and Without Attention-Deficit Hyperactivity Disorder
J Child Neurol, June 1, 1998; 13(6): 277 - 282.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. C. Harris, R. R. Lee, H. A. Jinnah, D. F. Wong, M. Yaster, and R. N. Bryan
Craniocerebral Magnetic Resonance Imaging Measurement and Findings in Lesch-Nyhan Syndrome
Arch Neurol, April 1, 1998; 55(4): 547 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
B. S. Peterson, P. Skudlarski, A. W. Anderson, H. Zhang, J. C. Gatenby, C. M. Lacadie, J. F. Leckman, and J. C. Gore
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome
Arch Gen Psychiatry, April 1, 1998; 55(4): 326 - 333.
[Abstract] [Full Text] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
P. R. Saba, K. Dastur, M. R. Raji, M. S. Keshavan, and M. A. Katerji
Obsessive-Compulsive Disorder, Tourette's Syndrome, and Basal Ganglia Pathology on MRI
J Neuropsychiatry Clin Neurosci, February 1, 1998; 10(1): 116 - 117.
[Full Text]

Home page
 J Learn DisabilHome page
E. D. Bigler, R. Lajiness-O'Neill, and N.-L. Howes
Technology in the Assessment of Learning Disability
J Learn Disabil, January 1, 1998; 31(1): 67 - 82.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
L. J. Schuerholz, L. Cutting, M. M. M. Mazzocco, H. S. Singer, and M. B. Denckla
Neuromotor Functioning in Children With Tourette Syndrome With and Without Attention Deficit Hyperactivity Disorder
J Child Neurol, October 1, 1997; 12(7): 438 - 442.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. H. Whitaker, R. Van Rossem, J. F. Feldman, I. S. Schonfeld, J. A. Pinto-Martin, C. Torre, D. Shaffer, and N. Paneth
Psychiatrie Outcomes in Low-Birth-Weight Children at Age 6 Years: Relation to Neonatal Cranial Ultrasound Abnormalities
Arch Gen Psychiatry, September 1, 1997; 54(9): 847 - 856.
[Abstract] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
N. Georgiou, J. L Bradshaw, J. G Phillips, R. Cunnington, and M. Rogers
Functional asymmetries in the movement kinematics of patients with Tourette's syndrome
J. Neurol. Neurosurg. Psychiatry, August 1, 1997; 63(2): 188 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
M. R. Pranzatelli
Topical Review: Antidyskinetic Drug Therapy for Pediatric Movement Disorders
J Child Neurol, September 1, 1996; 11(5): 355 - 369.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
F. X. Castellanos, J. N. Giedd, W. L. Marsh, S. D. Hamburger, A. C. Vaituzis, D. P. Dickstein, S. E. Sarfatti, Y. C. Vauss, J. W. Snell, N. Lange, et al.
Quantitative Brain Magnetic Resonance Imaging in Attention-Deficit Hyperactivity Disorder
Arch Gen Psychiatry, July 1, 1996; 53(7): 607 - 616.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
E. H. Aylward, A. L. Reiss, M. J. Reader, H. S. Singer, J. E. Brown, and M. B. Denckla
Basal Ganglia Volumes in Children With Attention-Deficit Hyperactivity Disorder
J Child Neurol, March 1, 1996; 11(2): 112 - 115.
[Abstract] [PDF]

Home page
 JAMAHome page
T. M. Hyde and D. R. Weinberger
Tourette's Syndrome: A Model Neuropsychiatric Disorder
JAMA, February 8, 1995; 273(6): 498 - 501.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1993 by AAN Enterprises, Inc.