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Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery (Dr. Doty, CM. Lehrach, and D.A. McKeown), and the Department of Neurology (Dr. Stern), School of Medicine, University of Pennsylvania, and the Graduate Hospital (Dr. Stern), Philadelphia, PA; and the Department of Neurology (Dr. Golbe), University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ.
Olfactory dysfunction occurs in most patients with idiopathic Parkinson's disease (PD). In this study, we sought to determine whether such dysfunction is also present in progressive supranuclear palsy (PSP), a condition which shares a number of motor symptoms with PD and is commonly misdiagnosed as PD. We administered the University of Pennsylvania Smell Identification Test, a standardized test of odor identification ability, to 21 PSP patients; 17 also received a forced-choice odor detection threshold test. We compared the olfactory test scores to those obtained from PD patients and normal controls matched to the PSP patients on the basis of age, sex, and smoking habits. Overall, the olfactory function of the PSP patients was markedly superior to that of the PD patients and did not differ significantly from that of the normal controls. There was no association in either the PSP or PD patient groups between (1) the olfactory test scores and (2) measures of motor symptom severity, disease stage, and medication usage. These findings demonstrate that patients with PSP and PD differ markedly in their ability to smell and suggest that olfactory testing may be useful in their differential diagnosis.
Address correspondence and reprint requests to Dr. Richard L. Doty, Smell and Taste Center, 5 Ravdin Institute, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.
Supported by grant RO1 AG 08148 from the National Institute on Aging and grant P01 DC 00161 from the National Institute on Deafness and Other Communication Disorders.
Received July 8, 1992. Accepted for publication in final form September 30, 1992.
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