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The 'embryonic' gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle

Department of Biochemistry (Drs. Horton, Manfredi, and Conti-Tronconi), University of Minnesota, St. Paul, and the Department of Pharmacology (Dr. Conti-Tronconi), University of Minnesota, Minneapolis, MN.

We have PCR-amplified cDNA sequence of the "embryonic" µM subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the µM subunit in EOM mRNA, but not in control skeletal muscle. The presence of y sub-unit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the y subunit is generally present.

Address correspondence and reprint requests to Dr. Bianca M. Conti-Tronconi, Department of Biochemistry, CBS, University of Minnesota, 174 Gortner Laboratories, 1479 Gortner Avenue, St. Paul, MN 55108.

Supported by NINCDS grant NS 29919, and by a grant from the Muscular Dystrophy Association of America (to B.M.C.-T.). R.M.H. is the recipient of a postdoctoral fellowship from the Muscular Dystrophy Association.

Received August 4, 1992. Accepted for publication in final form September 24, 1992.

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