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Detection of Borrelia burgdorferi antigens in cerebrospinal fluid

Departments of Neurology (Drs. Coyle, Belman, and Krupp, and Z. Deng), Pathology (Dr. Benach), and Medicine (Dr. Luft), Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY; and the Department of Medicine (Dr. Schutzer), University of Medicine and Dentistry of New Jersey, Newark, NJ.

We examined CSF for Borrelia burgdorferi antigens using antigen-capture ELISA and Western (immuno) blot. Antigen-capture ELISA was positive in 38 of 77 (49%) CSF samples obtained from neurologic patients with presumed B burgdorferi infection, compared with one of 34 (3%) CSF samples obtained from other neurologic disease controls who came from a region endemic for Lyme disease. Western immunoblot was positive for B burgdorferi antigens in 12 of 22 (55%) CSF samples from the B burgdorferi infected groups, compared with none of 11 CSF samples from the control group. CSF antigen detection should prove helpful in evaluating patients for suspected neurologic Lyme disease.

Address correspondence and reprint requests to Dr. P.K. Coyle, Department of Neurology, HSC T-12-020, SUNY at Stony Brook, Stony Brook, NY 11794.

Supported in part by NIH grants AR40470 and AI31561, a New York State grant for Lyme disease research, and the East End Lyme foundation; and by NIH grant AR41518 and CDC grant U50/CCU206582 (Dr. Schutzer).

Received August 27,1992. Accepted for publication in Final form October 12,1992.

Presented in part at the 44th annual meeting of the American Academy of Neurology, San Diego, CA, May 1992.

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