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NEUROLOGY 1993;43:1159
© 1993 American Academy of Neurology

Identical twins with similar onset of Parkinson's disease

A case report

Rajesh Pahwa, MD, Karen Busenbark, RN, Carolyn Gray, RN and William C. Roller, MD, PhD

Department of Neurology, University of Kansas Medical Center, Kansas City, KS.

The role of heredity in Parkinson's disease (PD) is controversial. We report a pair of monozygotic twins (confirmed by DNA fingerprints) concordant for PD. Their disease began when they were 62 and 63 years old. Both patients presented with left-side bradykinesia. One of the twins had a long history of depression. Both patients had typical manifestations of PD, which were responsive to dopaminergic therapy. The similar age of onset along with the similar clinical characteristics of these twins suggests that hereditary or genetic susceptibility may be important in the etiology of PD.

Address correspondence and reprint requests to Dr. Rajesh Pahwa, Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160.

Received August 3. 1992. Accepted for publication in final form October 26, 1992.






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