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NEUROLOGY 1993;43:1311
© 1993 American Academy of Neurology

Psychological stress as risk factor for exacerbations in multiple sclerosis

P. Nisipeanu, MD and A. D. Korczyn, MD, MSc

Departments of Neurology and Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.

We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower than expected based on the frequency during the preceding 2 years, suggesting that not all stress conditions increase the risk of exacerbations in MS.

Address correspondence and reprint requests to Professor A.D. Korczyn, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 69978, Israel.

Received September 16, 1992. Accepted for publication in final form November 17, 1992.




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