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Familial occurrence of migraine without aura and migraine with aura

Department of Neurology (Drs. Russell and Olesen), Gentofte Hospital, University of Copenhagen, Hellerup, and the Statistical Research Unit (Dr. Hilden) and Institute of Medical Genetics (Dr. Sørensen), University of Copenhagen, Copenhagen N, Denmark

We report a study of 121 probands (patients) with migraine without aura (MO) and 72 probands with migraine with aura (MA), diagnosed according to the operational diagnostic criteria of the International Headache Society and selected from 35 general practices in Denmark. The probands were interviewed about the presence of MO and MA among their first-degree relatives. Compared with the general population, the first-degree relatives of probands with MO had a threefold increase of MO, and only one first-degree relative of one proband with MO had MA. First-degree relatives of probands with MA had a twofold increase of both MA and MO. Compared with the general population, few spouses had MO and MA. This threefold and twofold increase in family risk of MO and MA, combined with the lack of increased risk in spouses, strongly suggests that MO and MA are genetically determined.

Address correspondence and reprint requests to Dr. Michael Bjørn Russell, Department of Neurology, Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.

Received September 17, 1992. Accepted for publication in final form November 23, 1992.

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