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NEUROLOGY 1993;43:1373
© 1993 American Academy of Neurology

Acetaminophen sulfation in patients with Parkinson's disease or Huntington's disease is not impaired

R.A.C. Roos, MD, PhD, J. M.C. Steenvoorden, MSc, G. J. Mulder, PhD and G. M.J. Van Kempen, PhD

Department of Neurology (Dr. Roos), Academic Hospital Leiden; the Center for Biopharmaceutical Sciences, Division of Toxicology (J. Steenvoorden and Dr. Mulder); the Department of Psychiatry (Dr. Van Kempen), State University Leiden, Leiden, and the Psychiatric Hospital Endegeest (Dr. Van Kempen), Oegstgeest, The Netherlands.

We studied acetaminophen sulfation, plasma sulfate levels, and the activity of sulfotransferase in blood platelets in patients with Parkinson's disease, Huntington's disease, and in controls and did not find any abnormality in the patient groups, independent of the use of medication.

Address correspondence and reprint requests to Dr. R.A.C. Roos, Department of Neurology, Academic Hospital Leiden, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

Received August 14,1992. Accepted for publication in final form November 13, 1992.






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