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NEUROLOGY 1993;43:1377
© 1993 American Academy of Neurology

A comparison of familial and sporadic Alzheimer's disease

R. Duara, MD, R. F. Lopez-Alberola, BS, W. W. Barker, MS, D. A. Loewenstein, PhD, M. Zatinsky, MSW, C. E. Eisdorfer, PhD, MD and G. B. Weinberg, MD

Wien Center for Alzheimer's Disease and Memory Disorders (Drs. Duara, Loewenstein, and Weinberg, and R.F. Lopez-Alberola, W.W. Barker, and M. Zatinsky), Mount Sinai Medical Center, Miami Beach, FL; and the Departments of Radiology and Neurology (Dr. Duara), Medicine (Dr. Weinberg), and Psychiatry (Drs. Loewenstein and Eisdorfer), University of Miami School of Medicine, Miami, FL.

Using a liberal criterion, a conservative probability-based criterion, and a criterion for autosomal dominant inheritance, we classified 36%, 13.5%, and 6.4% of 311 patients, respectively, as having familial Alzheimer's disease (FAD). The mean age of onset was over 70 years for all three categories of FAD. FAD and sporadic Alzheimer's disease (SAD) cases did not differ in clinical features, incidence of risk factors for dementia, or MRI or PET features. We observed earlier age of onset of AD to be related positively to longer duration of disease. Except for the autosomal dominant AD group, there was an earlier age of onset in FAD probands. The inheritance of AD from mothers was from 1.7 to 3.6 times more frequent than from fathers. Among SAD patients only, we found a preponderance of women, who were more frequently affected than would be expected from the male/female ratio in the general population of the same average age. Language performance tended to be less affected in FAD than in SAD patients, contrary to some previous reports.

Funded partially under an agreement with the Aging and Adult Services Program Office, Department of Health and Rehabilitative Services, State of Florida.

Address correspondence and reprint requests to Dr. Ranjan Duara, Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140.

Received June 15, 1992. Accepted for publication in final form November 18, 1992.




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