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Heterotopic neurons in amyotrophic lateral sclerosis

Department of Neuropathology, Institute of Pathology, The Royal London Hospital, Whitechapel, London, UK.

Heterotopic neurons in ALS have suggested aberrant neuronal migration during development. We studied 10 cases with ALS, 10 normal controls, and 10 cases with anterior horn cell disease, including spinal muscular atrophy and acute and remote poliomyelitis. There was no excess of heterotopic neurons in ALS compared with either control group and therefore no failure of neuronal migration in ALS.

Address correspondence and reprint requests to Dr. J.E. Martin, Department of Neuropathology, Institute of Pathology, The Royal London Hospital, Whitechapel, London E1 1BB, UK.

Supported by the Motor Neuron Disease Association of Great Britain. J.E.M. is a Wellcome Trust Fellow and holds the Gillson Scholarship in Pathology of the Worshipful Society of Apothecaries.

Received August 3, 1992. Accepted for publication in final form November 13, 1992.