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NEUROLOGY 1993;43:1690
© 1993 American Academy of Neurology

Antecedent clinical features associated with dementia in Parkinson's disease

Yaakov Stern, PhD, Karen Marder, MD, MPH, Ming Xi Tang, PhD and Richard Mayeux, MD

Departments of Neurology and Psychiatry, and the Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, NY.

In a prospective cohort study, we examined clinical features in 250 nondemented patients with idiopathic Parkinson's disease (PD) and then evaluated their association with incident dementia during 5 years of follow-up. Seventy-four of the patients became demented. Odds ratios for incident dementia with PD were increased for the following: being older than 70 years of age (2.7; 1.4 to 5.5), having a PD rating scale score greater than 25 (3.0; 1.5 to 6.2), being depressed (2.7; 1.5 to 6.6), being confused or psychotic on levodopa (3.3; 1.3 to 8.7), or having facial masking as a presenting sign (6.1; 1.4 to 26.9).

Address correspondence and reprint requests to Dr. Yaakov Stern, Neurological Institute, 710 West 168th Street, New York, NY 10032.

Supported by Federal Grants AG07232 and AG08702, The Parkinson's Disease Foundation, and the Charles S. Robertson Memorial Gift for Alzheimer's Disease.

Received November 4, 1992. Accepted for publication in final form January 6, 1993.




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