| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Neurology (Drs. Hubble and Roller and T. Cao), Biometry (Dr. Hassanein), and Preventive Medicine (Dr. Neuberger), University of Kansas Medical Center, Kansas City, KS.
Parkinson's disease (PD) has been associated with rural living, well-water consumption, and pesticide exposure; however, the individual risk contribution of these variables has not been established. We examined social and medical histories of predominantly rural populations to determine relative risk factors for PD. Patients and controls were surveyed regarding residency, occupation, medical history, and social and dietary habits. An initial multiple logistic regression model was confounded by excessive variable collinearity. Principal factor analysis yielded three factors: rural living (including years of rural residency and ground-water use), pesticide use, and male lifestyle (male gender, head trauma, male-dominated occupations). Other variables did not load in factor analysis and were entered separately, with the three factor scores, in a second multiple logistic regression model. Significant predictors of PD emerged (in order of strength): pesticide use, family history of neurologic disease, and history of depression. The predicted probability of PD was 92.3% (odds ratio = 12.0) with all three predictors positive. Pesticide use (distinguishable from rural living) can be considered a risk factor for the development of PD, with family history of neurologic disease and history of depression serving as weaker predictors of PD.
Address correspondence and reprint requests to Dr. Jean P. Hubble, Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7314.
Presented at the 44th annual meeting of the American Academy of Neurology, San Diego, CA, May 1992.
Received July 17, 1992. Accepted for publication in final form February 1, 1993.
This article has been cited by other articles:
|
|
 |
|
  S. Shavali and D. A. Sens Synergistic Neurotoxic Effects of Arsenic and Dopamine in Human Dopaminergic Neuroblastoma SH-SY5Y Cells Toxicol. Sci., April 1, 2008; 102(2): 254 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Fei, A. L. McCormack, D. A. Di Monte, and D. W. Ethell Paraquat Neurotoxicity Is Mediated by a Bak-dependent Mechanism J. Biol. Chem., February 8, 2008; 283(6): 3357 - 3364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Peng, L. Peng, F. F. Stevenson, S. R. Doctrow, and J. K. Andersen Iron and Paraquat as Synergistic Environmental Risk Factors in Sporadic Parkinson's Disease Accelerate Age-Related Neurodegeneration J. Neurosci., June 27, 2007; 27(26): 6914 - 6922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A D MURRAY Imaging in dementia Imaging, June 1, 2007; 19(2): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Wilk, J. E. Tobin, O. Suchowersky, H. A. Shill, C. Klein, G. F. Wooten, M. F. Lew, M. H. Mark, M. Guttman, R. L. Watts, et al. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study Neurology, December 26, 2006; 67(12): 2206 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Niso-Santano, J. M. Moran, L. Garcia-Rubio, A. Gomez-Martin, R. A. Gonzalez-Polo, G. Soler, and J. M. Fuentes Low Concentrations of Paraquat Induces Early Activation of Extracellular Signal-Regulated Kinase 1/2, Protein Kinase B, and c-Jun N-terminal Kinase 1/2 Pathways: Role of c-Jun N-Terminal Kinase in Paraquat-Induced Cell Death Toxicol. Sci., August 1, 2006; 92(2): 507 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Glatt, A. D. Wahner, D. J. White, A. Ruiz-Linares, and B. Ritz Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women Hum. Mol. Genet., January 15, 2006; 15(2): 299 - 305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Goldman, C. M. Tanner, C. W. Olanow, R. L. Watts, R. D. Field, and J. W. Langston Occupation and parkinsonism in three movement disorders clinics Neurology, November 8, 2005; 65(9): 1430 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Peng, F. F. Stevenson, S. R. Doctrow, and J. K. Andersen Superoxide Dismutase/Catalase Mimetics Are Neuroprotective against Selective Paraquat-mediated Dopaminergic Neuron Death in the Substantial Nigra: IMPLICATIONS FOR PARKINSON DISEASE J. Biol. Chem., August 12, 2005; 280(32): 29194 - 29198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Peng, X. O. Mao, F. F. Stevenson, M. Hsu, and J. K. Andersen The Herbicide Paraquat Induces Dopaminergic Nigral Apoptosis through Sustained Activation of the JNK Pathway J. Biol. Chem., July 30, 2004; 279(31): 32626 - 32632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Golomb, M. H. Criqui, H. White, and J. E. Dimsdale Conceptual Foundations of the UCSD Statin Study: A Randomized Controlled Trial Assessing the Impact of Statins on Cognition, Behavior, and Biochemistry Arch Intern Med, January 26, 2004; 164(2): 153 - 162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Bower, D. M. Maraganore, B. J. Peterson, S. K. McDonnell, J. E. Ahlskog, and W. A. Rocca Head trauma preceding PD: A case-control study Neurology, May 27, 2003; 60(10): 1610 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Niehaus and J H Lange Endotoxin: is it an environmental factor in the cause of Parkinson's disease? Occup. Environ. Med., May 1, 2003; 60(5): 378 - 378. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Petrovitch, G. W. Ross, R. D. Abbott, W. T. Sanderson, D. S. Sharp, C. M. Tanner, K. H. Masaki, P. L. Blanchette, J. S. Popper, D. Foley, et al. Plantation Work and Risk of Parkinson Disease in a Population-Based Longitudinal Study Arch Neurol, November 1, 2002; 59(11): 1787 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Norman, A. I. Troster, J. A. Fields, and R. Brooks Effects of Depression and Parkinson's Disease on Cognitive Functioning J Neuropsychiatry Clin Neurosci, February 1, 2002; 14(1): 31 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. E. Maher, L. I. Golbe, A. M. Lazzarini, M. H. Mark, L. J. Currie, G. F. Wooten, M. Saint-Hilaire, J. B. Wilk, J. Volcjak, J. E. Maher, et al. Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study Neurology, January 8, 2002; 58(1): 79 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L S Engel, H Checkoway, M C Keifer, N S Seixas, W T Longstreth Jr, K C Scott, K Hudnell, W K Anger, and R Camicioli Parkinsonism and occupational exposure to pesticides Occup. Environ. Med., September 1, 2001; 58(9): 582 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Deleu, W. A. Rocca, D. M. Maraganore, and M. D. Benedetti Smoking, alcohol, and coffee consumption preceding Parkinson's disease Neurology, April 10, 2001; 56(7): 984 - 985. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ritz and F. Yu Parkinson's disease mortality and pesticide exposure in California 1984-1994 Int. J. Epidemiol., April 1, 2000; 29(2): 323 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Elbaz, F. Grigoletto, M. Baldereschi, M. M. Breteler, J. M. Manubens-Bertran, S. Lopez-Pousa, J. F. Dartigues, A. Alperovitch, C. Tzourio, and W. A. Rocca Familial aggregation of Parkinson's disease: A population-based case-control study in Europe Neurology, June 1, 1999; 52(9): 1876 - 1876. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. L. Cummings Understanding Parkinson Disease JAMA, January 27, 1999; 281(4): 376 - 378. [Full Text] [PDF]
|
|
|
|
 |
|
 D K Y Chan, J Woo, S C Ho, C P Pang, L K Law, P W Ng, W T Hung, T Kwok, E Hui, K Orr, et al. Genetic and environmental risk factors for Parkinson's disease in a Chinese population J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 781 - 784. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
