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NEUROLOGY 1993;43:1728
© 1993 American Academy of Neurology

A familial syndrome with cutaneous malignant melanoma and cerebral astrocytoma

David K. Kaufman, MD, David W. Kimmel, MD, Joseph E. Parisi, MD and Virginia V. Michels, MD

Departments of Neurology (Drs. Kaufman and Kimmel), Laboratory Medicine and Pathology (Dr. Parisi), and Medical Genetics (Dr. Michels), Mayo Clinic and Mayo Foundation, Rochester, MN.

We describe a family in which cutaneous malignant melanoma or cerebral astrocytoma, or both, developed in eight members over three generations. Other malignancies also occurred with a lesser frequency. In two patients with both malignant melanoma and astrocytoma, the brain tumor followed the diagnosis of melanoma by a period of 2 and 10 years and was the primary cause of morbidity and mortality. The findings in this family may represent a newly described genetic disorder.

Address correspondence and reprint requests to Dr. David Kimmel, Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Supported in part by research grant CA50905 from the National Cancer Institute.

Received October 22, 1992. Accepted for publication in final form January 22, 1993.




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