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NEUROLOGY 1993;43:1779
© 1993 American Academy of Neurology

Incidence and prevalence of myasthenia gravis in western Denmark

1975 to 1989

P. B. Christensen, MD, T. S. Jensen, MD, PhD, I. Tsiropoulos, MD, T. Søsrensen, MD, M. Kjser, MD, PhD, E. Højer-Pedersen, MD, M.J.K. Rasmussen, MD, E. Lehfeldt, MD and B. de Fine Olivarius, MD, PhD

Departments of Neurology, Aarhus University Hospital (Drs. Christensen, Jensen, and de Fine Olivarius), Aarhus; Odense University Hospital (Dr. Tsiropoulos), Odense; Viborg Hospital (Dr. Søsrensen), Viborg; Holstebro Hospital (Dr. Kjær), Holstebro; Vejle Hospital (Dr. Høsjer-Pedersen), Vejle; Sønderborg Hospital (Dr. Rasmussen), Sønderborg; and Esbjerg Hospital (Dr. Lehfeldt), Esbjerg, Denmark.

We studied the epidemiology of myasthenia gravis (MG) in western Denmark from 1975 to 1989, basing case identification on records from all hospitals in the survey area. The population surveyed was 2.80 million in 1985. The average annual incidence rate was 5.0 per million population (women, 5.9; men, 4.2). The point-prevalence rate (January 1, 1990) was 78 per million population (women, 102; men, 53). In men, the incidence increased after 40 years. In women, the incidence rates showed a bimodal pattern with a peak of 7.0 in the age group 20 to 29 years and a second peak of 11.7 in the age group 70 to 79 years. The differences in sex- and age-specific incidence rates suggest that younger women are more susceptible to MG than younger men. Old men and postmenopausal women had similar rates. When last examined, 21% of the 220 prevalent cases were in remission and 18% were moderately or severely disabled.

Address correspondence and reprint requests to Dr. Peter Brøgger Christensen, Department of Neurology, Aarhus University Hospital, Aarhus Kommunehospital, 8000 Aarhus, Denmark.

Received May 1, 1992. Accepted for publication in final form January 12, 1993.




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