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NEUROLOGY 1993;43:1789
© 1993 American Academy of Neurology

Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy

D. W. Loring, PhD, A. M. Murro, MD, K. J. Meador, MD, G. P. Lee, PhD, C. A. Gratton, PhD, M. E. Nichols, MD, B. B. Gallagher, MD, PhD, D. W. King, MD and J. R. Smith, MD

Departments of Neurology (Drs. Loring, Murro, Meador, Gratton, Nichols, Gallagher, and King), Psychiatry (Dr. Lee), and Surgery (Neurosurgery) (Drs. Lee and Smith), Medical College of Georgia, Augusta, GA.

We examined the relationship of Wada memory performance and MRI hippocampal volume measurements to laterality of ultimate seizure localization in 20 patients with complex partial seizures who later underwent temporal lobectomy. Discriminant function analysis employing both Wada memory test asymmetries and hippocampal volume asymmetries correctly classified 100% of the patients into left and right temporal lobe groups. Wada memory asymmetries alone correctly classified 90% of the sample (80% of the sample when the discriminant function included all patients except the one being classified), and hippocampal volume asymmetries alone correctly classified 90% of the patients. A significant correlation was present between Wada memory asymmetries and hippocampal volume asymmetries (r = 0.78), indicating that structural evidence of reduced hippocampal volume has a functional correlate reflected by Wada memory performance. These data suggest that the combination of functional and structural measures is of value in the preoperative evaluation for epilepsy surgery.

Presented at the 21st annual meeting of the International Neuropsychological Society, Galveston, TX, February 1993.

Address correspondence and reprint requests to Dr. David W. Loring, Section of Behavioral Neurology, Department of Neurology, Medical College of Georgia, Augusta, GA 30912-3275.

Received November 30,1992. Accepted for publication in final form February 2,1993.




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