| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neurosciences Unit and the Radiology and Physics Unit, Institute of Child Health, Great Ormond St., London (Drs. Jackson and Connelly and Prof. Gadian) and the Epilepsy Research Group, Institute of Neurology, Queen Square, London (Drs. Jackson, Duncan, and Grtinewald).
Abnormal T2-weighted signal intensity in the hippocampus may be difficult to detect visually, and T2 mapping provides an objective means of assessing signal abnormality. We investigated 50 adult outpatients suffering from intractable partial epilepsy with MRI optimized to detect hippocampal and cortical gray matter abnormalities, and with MR T2 relaxation mapping. The range of normal hippocampal T2 relaxation times is small (99 to 106 msec), and the measurements are reproducible between observers. There were abnormal hippocampal T2 relaxation times in the hippocampus ipsilateral to the site of seizure origin in 70% of patients studied, with the more severe abnormality in the ipsilateral hippocampus in all cases. All hippocampal T2 measurements greater than 116 msec were associated with temporal lobe epilepsy and pathologic or MRI evidence of hippocampal sclerosis, or both. Bilateral abnormalities were present in 29% of cases with hippocampal sclerosis.
Address correspondence and reprint requests to Dr. Graeme D. Jackson, Clinical Senior Lecturer, Neurosciences Unit, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, UK.
Received August 18, 1992. Accepted for publication in final form January 15, 1993.
This article has been cited by other articles:
|
|
 |
|
  C. F. Hagmann, E. De Vita, A. Bainbridge, R. Gunny, A. B. Kapetanakis, W. K. Chong, E. B. Cady, D. G. Gadian, and N. J. Robertson T2 at MR Imaging Is an Objective Quantitative Measure of Cerebral White Matter Signal Intensity Abnormality in Preterm Infants at Term-equivalent Age Radiology, July 1, 2009; 252(1): 209 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hanamiya, Y. Korogi, S. Kakeda, N. Ohnari, K. Kamada, J. Moriya, T. Sato, M. Kitajima, N. Akamatsu, and S. Tsuji Partial Loss of Hippocampal Striation in Medial Temporal Lobe Epilepsy: Pilot Evaluation with High-Spatial-Resolution T2-weighted MR Imaging at 3.0 T Radiology, June 1, 2009; 251(3): 873 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Baxendale, P. J. Thompson, and J. S. Duncan Evidence-Based Practice: A Reevaluation of the Intracarotid Amobarbital Procedure (Wada Test) Arch Neurol, June 1, 2008; 65(6): 841 - 845. [Full Text] [PDF]
|
|
|
|
 |
|
 P.A. Bartlett, M.R. Symms, S.L. Free, and J.S. Duncan T2 Relaxometry of the Hippocampus at 3T AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1095 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.M. G. Pereira, E. Oliveira, and P. Rosado Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy AJNR Am. J. Neuroradiol., March 1, 2006; 27(3): 671 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J. Rugg-Gunn, P. A. Boulby, M. R. Symms, G. J. Barker, and J. S. Duncan Whole-brain T2 mapping demonstrates occult abnormalities in focal epilepsy Neurology, January 25, 2005; 64(2): 318 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Symms, H R Jager, K Schmierer, and T A Yousry A review of structural magnetic resonance neuroimaging J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1235 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Maillard, R. Jones, C. Owens, C. Pilkington, P. Woo, L. R. Wedderburn, and K. J. Murray Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis Rheumatology, May 1, 2004; 43(5): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Briellmann, A. Syngeniotis, S. Fleming, R. M. Kalnins, D. F. Abbott, and G. D. Jackson Increased Anterior Temporal Lobe T2 Times in Cases of Hippocampal Sclerosis: A Multi-Echo T2 Relaxometry Study At 3 T AJNR Am. J. Neuroradiol., March 1, 2004; 25(3): 389 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Scott, J. H. Cross, D. G. Gadian, G. D. Jackson, B. G. R. Neville, and A. Connelly Abnormalities in hippocampi remote from the seizure focus: a T2 relaxometry study Brain, September 1, 2003; 126(9): 1968 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Duncan Seizure-induced neuronal injury: Human data Neurology, November 12, 2002; 59(90095): S15 - 20. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. L. So Role of Neuroimaging in the Management of Seizure Disorders Mayo Clin. Proc., November 1, 2002; 77(11): 1251 - 1264. [Abstract] [PDF]
|
|
|
|
|
|
J. von Oertzen, H. Urbach, I. Blumcke, M. Reuber, F. Traber, T. Peveling, C. Menzel, and C. E. Elger Time-efficient T2 relaxometry of the entire hippocampus is feasible in temporal lobe epilepsy Neurology, January 22, 2002; 58(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Briellmann, R. M. Kalnins, S. F. Berkovic, and G. D. Jackson Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis Neurology, January 22, 2002; 58(2): 265 - 271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R A Grunewald, T Farrow, P Vaughan, C D C Rittey, and J Mundy A magnetic resonance study of complicated early childhood convulsion J. Neurol. Neurosurg. Psychiatry, November 1, 2001; 71(5): 638 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Georgiades, R. Itoh, X. Golay, P. C. M. van Zijl, and E. R. Melhem MR Imaging of the Human Brain at 1.5 T: Regional Variations in Transverse Relaxation Rates in the Cerebral Cortex AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1732 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Diehl, I. Najm, A. Mohamed, E. Wyllie, T. Babb, Z. Ying, A. Hilbig, W. Bingaman, H. O. Luders, and P. Ruggieri Fluid-attenuated inversion recovery: Correlations of hippocampal cell densities with signal abnormalities Neurology, September 25, 2001; 57(6): 1029 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Briellmann, M. R. Newton, R. M. Wellard, and G. D. Jackson Hippocampal sclerosis following brief generalized seizures in adulthood Neurology, July 24, 2001; 57(2): 315 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lamusuo, L. Jutila, A. Ylinen, R. Kalviainen, E. Mervaala, M. Haaparanta, S. Jaaskelainen, K. Partanen, M. Vapalahti, and J. Rinne [18F]FDG-PET Reveals Temporal Hypometabolism in Patients With Temporal Lobe Epilepsy Even When Quantitative MRI and Histopathological Analysis Show Only Mild Hippocampal Damage Arch Neurol, June 1, 2001; 58(6): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Park, K.-H. Chang, H.-D. Kim, I. C. Song, D. S. Lee, S. K. Lee, C.-K. Chung, I. K. Yu, M. H. Han, and Y. H. Park Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography AJNR Am. J. Neuroradiol., April 1, 2001; 22(4): 625 - 631. [Abstract] [Full Text]
|
|
|
|
|
|
S. Lamusuo, A. Pitkanen, L. Jutila, A. Ylinen, K. Partanen, R. Kalviainen, H.-M. Ruottinen, V. Oikonen, K. Nagren, P. Lehikoinen, et al. [11C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy: Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology Neurology, June 27, 2000; 54(12): 2252 - 2260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Gadian, J. Aicardi, K. E. Watkins, D. A. Porter, M. Mishkin, and F. Vargha-Khadem Developmental amnesia associated with early hypoxic-ischaemic injury Brain, March 1, 2000; 123(3): 499 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J H Cross Update on surgery for epilepsy Arch. Dis. Child., October 1, 1999; 81(4): 356 - 359. [Full Text]
|
|
|
|
|
|
L. A. Mitchell, G. D. Jackson, R. M. Kalnins, M. M. Saling, G. J. Fitt, R. D. Ashpole, and S. F. Berkovic Anterior temporal abnormality in temporal lobe epilepsy: A quantitative MRI and histopathologic study Neurology, January 1, 1999; 52(2): 327 - 327. [Abstract] [Full Text]
|
|
|
|
|
|
F. G Woermann, G. J Barker, K. D Birnie, H. J Meencke, and J. S Duncan Regional changes in hippocampal T2 relaxation and volume: a quantitative magnetic resonance imaging study of hippocampal sclerosis J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 656 - 664. [Abstract] [Full Text]
|
|
|
|
|
|
A. Connelly, W. Van Paesschen, D. A. Porter, C. L. Johnson, J. S. Duncan, and D. G. Gadian Proton magnetic resonance spectroscopy in MRI-negative temporal lobe epilepsy Neurology, July 1, 1998; 51(1): 61 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Jackson, A. M. McIntosh, R. S. Briellmann, and S. F. Berkovic Hippocampal sclerosis studied in identical twins Neurology, July 1, 1998; 51(1): 78 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Watson, C. R. Jack Jr, and F. Cendes Volumetric Magnetic Resonance Imaging: Clinical Applications and Contributions to the Understanding of Temporal Lobe Epilepsy Arch Neurol, December 1, 1997; 54(12): 1521 - 1531. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Vargha-Khadem, D. G. Gadian, K. E. Watkins, A. Connelly, W. Van Paesschen, and M. Mishkin Differential Effects of Early Hippocampal Pathology on Episodic and Semantic Memory Science, July 18, 1997; 277(5324): 376 - 380. [Abstract] [Full Text]
|
|
|
|
|
|
R. L. Gilmore, M. D. Childress, C. Leonard, R. Quisling, S. Roper, S. Eisenschenk, and M. Mahoney Hippocampal Volumetrics Differentiate Patients With Temporal Lobe Epilepsy and Extratemporal Lobe Epilepsy Arch Neurol, August 1, 1995; 52(8): 819 - 824. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Vargha-Khadem, E. Isaacs, and V. Muter A Review of Cognitive Outcome After Unilateral Lesions Sustained During Childhood J Child Neurol, October 1, 1994; 9(2_suppl): 2S67 - 2S73. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
