NEUROLOGY 1993;43:1800
© 1993 American Academy of Neurology
MRI hippocampal volumes and memory function before and after temporal lobectomy
M. R. Trenerry, PhD,
C. R. Jack, Jr., MD,
R. J. Ivnik, PhD,
F. W. Sharbrough, MD,
G. D. Cascino, MD,
K. A. Hirschorn, MD,
W. R. Marsh, MD,
P. J. Kelly, MD and
F. B. Meyer, MD
Departments of Psychiatry and Psychology (Drs. Trenerry and Ivnik), Diagnostic Radiology (Dr. Jack), Neurology (Drs. Sharbrough, Cascino, and Hirschorn), and Neurologic Surgery (Drs. Marsh, Kelly, and Meyer), Mayo Clinic and Mayo Foundation, Rochester, MN.
We investigated the relationship between preoperative MRI hippocampal volumes and clinical neuropsychological memory test data obtained before and after temporal lobectomy and amygdalohippocampectomy for intractable epilepsy in 44 left (LTL) and 36 right (RTL) temporal lobectomy patients. In LTL patients, the difference (right minus left hippocampal volume) between hippocampal volumes (DHF) was significantly (p < 0.001) correlated (r = 0.61) with postoperative verbal memory change as measured by a delayed memory percent retention score from the Wechsler Memory Scale-Revised, Logical Memory subtest. DHF was also positively associated with postoperative memory for abstract geometric designs in LTL patients (r = 0.49, p < 0.005). Resection of a relatively nonatrophic left hippocampus was associated with poorer verbal and visual memory outcome. In RTL patients, larger right adjusted (for total intracranial volume) hippocampal volume was associated with decline in visual-spatial learning, but not memory, following surgery. MRI hippocampal volume data appear to provide meaningful information in evaluating the risk for memory impairment following temporal lobectomy.
Address correspondence and reprint requests to Dr. Max R. Trenerry, Section of Psychology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905.
Supported in part by grant #R55 NS28374-01A1 from the National Institutes of Health awarded to C.R. Jack, Jr., MD.
Presented in part at the annual meeting of the American Epilepsy Society, Philadelphia, PA, December 8 to 11, 1991.
Received August 25,1992. Accepted for publication in final form January 26, 1993.
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