HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Podikoglou, D. G. Articles by Papavassiliou, J. Th. Search for Related Content PubMed PubMed Citation Articles by Podikoglou, D. G. Articles by Papavassiliou, J. Th.

Polymorphonuclear leukocyte functions and multiple sclerosis

Department of Microbiology, Athens University Medical School, Goudi, Athens, Greece.

We tested peripheral blood from 60 patients with definite multiple sclerosis (MS) and 60 healthy controls for polymorphonuclear leukocyte (PMNL) functions and found significant disorders in adherence (9.07% ± 8.18% for patients versus 28.97% ± 5.76% for controls), chemotaxis (18.32 ± 3.1 for patients versus 30.49 ± 4.52 for controls), phagocytosis (73.6 ± 25.25 for patients versus 111.2 ± 25.7 for controls), and bactericidal action (10.35% ± 5% for patients versus 25.09% ± 4.82% for controls). All differences were significant (p < 0.001). We confirmed the results by retesting 3 to 8 months later. The depressed PMNL functions in MS patients may explain their increased susceptibility to infections of the respiratory, digestive, and urinary tracts.

Address correspondence and reprint requests to Dr. Danis G. Podikoglou, 68 Spetson Street, Kipseli, Athens 11362, Greece.

Received April 7, 1992. Accepted for publication in final form June 17, 1993.

This article has been cited by other articles:

				J. Debruyne, J. Philippe, J. Dereuck, A. Willems, and G. Leroux-Roels Relapse markers in multiple sclerosis: are in vitro cytokine production changes reflected by circulatory T-cell phenotype alterations? Multiple Sclerosis, June 1, 1998; 4(3): 193 - 197. [Abstract] [PDF]