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NEUROLOGY 1994;44:152
© 1994 American Academy of Neurology

Delayed postanoxic demyelination and arylsulfatase-A pseudodeficiency

L. M. Weinberger, MD, J. W. Schmidley, MD, I. A. Schafer, MD and S. Raghavan, PhD

Departments of Neurology (Drs. Weinberger and Schmidley) and Pediatrics (Dr. Schafer), Case Western Reserve University School of Medicine, Cleveland, OH; and the Department of Neurology (Dr.Raghavan), New York University School of Medicine, New York, NY.

We report a patient with delayed postanoxic demyelination who had pseudodeficiency of arylsulfatase A, reducing his enzyme activity to 10 to 30% of normal. This may have implications regarding the pathogenesis of postanoxic demyelination.

Address correspondence and reprint requests t o Dr. Leonard M. Weinberger, Department of Neurology, The Graduate Hospital, 19th and Lombard Streets, Philadelphia, PA 19146.

Received May 3, 1993. Accepted for publication in final form June 18, 1993.




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