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Prevalence of essential tremor

A door-to-door survey in Terrasini, Sicily

Department of Neurology (Drs. Salemi, Savettieri, and Saporito), University of Palermo, Palermo; the Italian Multicenter Study on Dementia, SMID Center (Dr. Rocca), Florence; the Department of Biostatistics and Epidemiology (Dr. Meneghinil, Fidia Research Laboratories, Abano Terme; the Department of Neurology (Drs. Morgante and Di Perri), University of Messina, Messina; the Department of Neurology (Dr. Reggio), University of Catania, Catania; and the Institute of Hygiene (Dr. Grigoletto), University of Padua, Padua, Italy.

As part of a door-to-door neuroepidemiologic survey, we investigated the frequency and distribution of essential tremor (ET) in a Sicilian municipality. During phase 1, we administered a screening instrument for tremor to 7,653 persons residing in Terrasini (Palermo province). During phase 2, neurologists evaluated those subjects who had screened positive. The diagnoses, based on specified clinical criteria, were reviewed to increase reliability across neurologists. We found 31 subjects affected by ET (17 men, 14 women); 11 patients (35.5%) reported a familial aggregation. The prevalence of ET as of November 1, 1987, was 405.1 per 100,000 for the total population, and 1,074.9 per 100,000 for those 40 years old or older. The prevalence increased with advancing age for both sexes and was slightly but consistently higher in men. Comparison with other studies suggests striking geographic variation, which may reflect genetic differences.

Address correspondence and reprint requests to Dr. G. Salemi, Istituto di Neuropsichiatria, Universitá di Palermo, Via Gaetano La Loggia 1, 90129 Palermo, Italy.

Supported by the Assessorato alla Sanitá della Regione Sicilia (Grant N 58/P) and by Fidia Research Laboratories, Abano Terme, Italy.

Presented in part a t the 43rd annual meeting of the American Academy of Neurology, Boston, MA, April 1991.

Received March 22, 1993. Accepted for publication in final form July 7, 1993.

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