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Departments of Behavioral Neurology and Neuropsychiatry (Drs. Starkstein, Petracca, Sabe, Migliorelli, and Teson), Nuclear Medicine (Drs. Starkstein and Vazquez), and Clinical Neurology (Drs. Starkstein and Leiguarda), Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Although delusions are a frequent finding in patients with Alzheimer's disease (AD), their mechanism is not well known. We carried out Tc 99m HMPAO single-photon emission computed tomography studies in 16 AD patients with delusions and 29 AD patients without delusions comparable in age, years of education, duration of illness, and severity of dementia. Although we found no significant between-group differences in performance on neuropsychological tasks, AD patients with delusions had significantly lower mean cerebral blood flow in both the left and right temporal lobes.
Address correspondence and reprint requests to Dr. Sergio E. Starkstein, Institute de Investigaciones Neurológicas Raúl Carrea-FLENI, Montaneses 2325, 1428 Buenos Aires, Argentina.
Supported in part by grants from the Raul Carrea Institute of Neurological Research and the Sandoz Foundation.
Received February 11, 1994. Accepted in final form May 10, 1994.
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