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NEUROLOGY 1994;44:2101
© 1994 American Academy of Neurology

Striatal dopamine D2 receptors in patients with narcolepsy measured with PET and 11C-raclopride

N. Khan, MD, A. Antonini, MD, D. Parkes, MD, M. J. Dahlitz, MD, K. Meier-Ewert, MD, A. Weindl, MD and K. L. Leenders, MD

PET Department (Drs. Khan, Antonini, and Leenders), Paul Scherrer Institute, Villigen, Switzerland; the Department of Neurology (Drs. Parkes and Dahlitz), University of London, United Kingdom; Neurology Hospital Hephata (Dr. Meier-Ewert), Treysa, Germany; and the Department of Neurology (Dr. Weindl), University of Miinchen, Munich, Germany.

We investigated in vivo D2 receptor binding using 11C-raclopride and PET in the striatum of 17 subjects with the narcoleptic syndrome. Putamen and caudate nucleus 11C-raclopride uptake was comparable in the total patient group and controls, and the tracer uptake was similar in the HLA-DR2-positive (n = 12) and HLA-DR2-negative (n = 5) narcoleptic subjects. There was a significant increase in 11C-raclopride uptake in the putamen of narcoleptic subjects older than 31 years (n = 11) when compared with age-matched controls (n = 15). There was no evidence of involvement of the striatal D2 dopaminergic neurotransmitter system in the basic pathophysiology of the narcoleptic syndrome despite an age-related increase in putaminal 11C-raclopride uptake.

Address correspondence and reprint requests to Dr. K.L. Leenders, Paul Scherrer Institute, CH-5232 Villigen, Switzerland.

Supported in part by the Swiss National Research Foundation, grant no. 31-30079.90.

Received February 16, 1994. Accepted in final form May 11, 1994.






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