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NEUROLOGY 1994;44:2115
© 1994 American Academy of Neurology

Oral and genital tardive pain syndromes

Blair Ford, MD, FRCP(C), Paul Greene, MD and Stanley Fahn, MD

Neurological Institute, Columbia-Presbyterian Medical Center, New York, NY.

We report the development of chronic painful oral or genital sensations in 11 patients with tardive akathisia, tardive dyskinesias, or tardive dystonia. In each case, the pain syndrome became a source of profound distress for the patient, overshadowing all other concurrent neuropsychiatric symptoms, and requiring treatment. Agents effective in treating tardive dyskinesia and tardive akathisia, such as catecholamine depletors, proved effective in reducing the painful sensations. Our observations support the concept of tardive pain as a complication of chronic neuroleptic exposure.

Address correspondence and reprint requests to Dr. Blair Ford, Neurological Institute, 710 W. 168th Street, New York, NY 10032.

Dr. Ford is supported by the Myoclonus Research Foundation.

Received December 2, 1993. Accepted in final form May 31, 1994.

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