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Center for Neurologic Diseases (Drs. Khoury, Hohol, Mackin, and Weiner) and the Radiology Department (Drs. Guttmann, Ahn, Hsu, Kikinis, and Jolesz), Brigham and Women's Hospital, Boston, MA; and the Biostatistic Department (Dr. Orav), Harvard School of Public Health, Boston, MA.
We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.
Address correspondence and reprint requests to Dr. S.J. Khoury, Center for Neurologic Diseases, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115.
Supported by NIH contract NO1-NS-0-2397, and in part by NIH grant NCRR GCRC MO1 to the Brigham and Women's Hospital General Clinical Research Center.
Received February 28, 1994. Accepted in final form May 11, 1994.
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