| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Center for Neurologic Diseases (Drs. Khoury, Hohol, Mackin, and Weiner) and the Radiology Department (Drs. Guttmann, Ahn, Hsu, Kikinis, and Jolesz), Brigham and Women's Hospital, Boston, MA; and the Biostatistic Department (Dr. Orav), Harvard School of Public Health, Boston, MA.
We followed 18 multiple sclerosis patients clinically and with repeated brain MRIs with and without gadolinium for over 1 year. Clinical evaluations included scoring on the Kurtzke Expanded Disability Status Scale (EDSS) and the Ambulation Index (AI) scale. There was a significant correlation between the change in EDSS or AI and the change in number of lesions on MRI and between cumulative number of lesions on MRI and cumulative change in EDSS or AI. Our findings support the validity of MRI as a measure of clinical activity and potentially as an objective quantitative outcome measure for assessing response to therapy.
Address correspondence and reprint requests to Dr. S.J. Khoury, Center for Neurologic Diseases, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115.
Supported by NIH contract NO1-NS-0-2397, and in part by NIH grant NCRR GCRC MO1 to the Brigham and Women's Hospital General Clinical Research Center.
Received February 28, 1994. Accepted in final form May 11, 1994.
This article has been cited by other articles:
|
|
 |
|
  W Rashid, G R Davies, D T Chard, C M Griffin, D R Altmann, A J Thompson, and D H Miller Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal study Multiple Sclerosis, March 1, 2007; 13(2): 178 - 185. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Correale, M. Fiol, and W. Gilmore The risk of relapses in multiple sclerosis during systemic infections Neurology, August 22, 2006; 67(4): 652 - 659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bakshi, G. J. Hutton, J. R. Miller, and E.-W. Radue The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosis Neurology, December 14, 2004; 63(11_suppl_5): S3 - S11. [Abstract] [Full Text]
|
|
|
|
|
|
V L Stevenson, G T Ingle, D H Miller, and A J Thompson Magnetic resonance imaging predictors of disability in primary progressive multiple sclerosis: a 5-year study Multiple Sclerosis, August 1, 2004; 10(4): 398 - 401. [Abstract] [PDF]
|
|
|
|
|
|
F. Cotton, H. L. Weiner, F. A. Jolesz, and C. R.G. Guttmann MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals Neurology, February 25, 2003; 60(4): 640 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Galetta, C. Markowitz, and A. G. Lee Immunomodulatory Agents for the Treatment of Relapsing Multiple Sclerosis: A Systematic Review Arch Intern Med, October 28, 2002; 162(19): 2161 - 2169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zivadinov, R. A. Rudick, R. De Masi, D. Nasuelli, M. Ukmar, R. S. Pozzi-Mucelli, A. Grop, G. Cazzato, and M. Zorzon Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS Neurology, October 9, 2001; 57(7): 1239 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K.B. Li, G. J. Zhao, and D. W. Paty Randomized controlled trial of interferon-beta-1a in secondary progressive MS: MRI results Neurology, June 12, 2001; 56(11): 1505 - 1513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N A Losseff, D H Miller, D Kidd, and A J Thompson The predictive value of gadolinium enhancement for long term disability in relapsing-remitting multiple sclerosis-preliminary results Multiple Sclerosis, February 1, 2001; 7(1): 23 - 25. [Abstract] [PDF]
|
|
|
|
 |
|
 R. A. Sperling, C. R. G. Guttmann, M. J. Hohol, S. K. Warfield, M. Jakab, M. Parente, E. L. Diamond, K. R. Daffner, M. J. Olek, E. J. Orav, et al. Regional Magnetic Resonance Imaging Lesion Burden and Cognitive Function in Multiple Sclerosis: A Longitudinal Study Arch Neurol, January 1, 2001; 58(1): 115 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T L Luks, D E Goodkin, S J Nelson, S Majumdar, P Bacchetti, D Portnoy, and R Sloan A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis Multiple Sclerosis, October 1, 2000; 6(5): 332 - 337. [Abstract] [PDF]
|
|
|
|
|
|
T. F. Scott, C. J. Schramke, J. Novero, and C. Chieffe Short-term prognosis in early relapsing-remitting multiple sclerosis Neurology, September 12, 2000; 55(5): 689 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ge, R. I. Grossman, J. K. Udupa, L. Wei, L. J. Mannon, M. Polansky, and D. L. Kolson Brain Atrophy in Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis: Longitudinal Quantitative Analysis Radiology, March 1, 2000; 214(3): 665 - 670. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Ge, R. I. Grossman, J. K. Udupa, J. Fulton, C. S. Constantinescu, F. Gonzales-Scarano, J. S. Babb, L. J. Mannon, D. L. Kolson, and J. A. Cohen Glatiramer acetate (Copaxone) treatment in relapsing-remitting MS: Quantitative MR assessment Neurology, February 22, 2000; 54(4): 813 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Khoury, E. J. Orav, C. R. G. Guttmann, R. Kikinis, F. A. Jolesz, and H. L. Weiner Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis Neurology, September 1, 1999; 53(4): 758 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Barkhof MRI in multiple sclerosis: correlation with expanded disability status scale (EDSS) Multiple Sclerosis, August 1, 1999; 5(4): 283 - 286. [Abstract] [PDF]
|
|
|
|
|
|
P. S. Surensen Biological markers in body fluids for activity and progression in multiple sclerosis Multiple Sclerosis, August 1, 1999; 5(4): 287 - 290. [Abstract] [PDF]
|
|
|
|
 |
|
 Rovaris, Comi, M. Rocca, Cercignani, Colombo, Santuccio, and Filippi Relevance of Hypointense Lesions on Fast Fluid-Attenuated Inversion Recovery MR Images as a Marker of Disease Severity in Cases of Multiple AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 813 - 820. [Abstract] [Full Text]
|
|
|
|
 |
|
 X. Bosch, J. L. Levenson, R. Martin-Bermudez, F. Murillo-Cabezas, J. M. Dominguez-Roldan, P. M. Reilly, A. Alavi, D. H. Jenkins, and S. Gilman Imaging the Brain N. Engl. J. Med., August 6, 1998; 339(6): 407 - 409. [Full Text]
|
|
|
|
|
|
S. J. Khoury and H. L. Weiner Multiple Sclerosis: What Have We Learned From Magnetic Resonance Imaging Studies? Arch Intern Med, March 23, 1998; 158(6): 565 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M L Gawne-Cain, J I O'Riordan, A Coles, B Newell, A J Thompson, and D H Miller MRI lesion volume measurement in multiple sclerosis and its correlation with disability: a comparison of fast fluid attenuated inversion recovery (fFLAIR) and spin echo sequences J. Neurol. Neurosurg. Psychiatry, February 1, 1998; 64(2): 197 - 203. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
