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Olfactory function in Parkinson's disease subtypes

Movement Disorders Center, Department of Neurology (P. Corcoran and Drs. Adler, Dotti, Gollomp, Hurtig, and Stern), Graduate Hospital, Philadelphia, PA; the Department of Neurology (Drs. Hurtig and Stern), University of Pennsylvania School of Medicine, Philadelphia, PA; and the Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery (Dr. Doty and D. Crawford and D.A. McKeown), Hospital of the University of Pennsylvania, Philadelphia, PA.

Decreased olfactory function commonly occurs in idiopathic Parkinson's disease (PD), regardless of stage, treatment, or duration of disease. In the present study, we sought to determine whether different subtypes of PD, categorized according to well-defined clinical criteria, evidence different degrees of olfactory dysfunction. Significantly different scores on the University of Pennsylvania Smell Identification Test (UPSIT) were present between patients with benign PD and malignant PD (respective means [SD] = 22.51 [8.50] and 17.38 [6.29]) and between tremor-predominant PD and postural instability-gait disorder (PIGD)-predominant PD (23.43 [8.18] versus 17.35 [6.00]). No statistically significant differences in UPSIT scores were observed between young-onset and older-onset PD patients. Women outperformed men in most subtypes examined.

Address correspondence and reprint requests to Dr. Matthew B. Stern, Department of Neurology, Graduate Hospital, 18th and Lombard Street, Philadelphia, PA 19146.

Presented in part at the 44th annual meeting of the American Academy of Neurology, San Diego, CA, May 1992.

Supported by a grant from the National Parkinson Foundation (Dr. Stern), grant R0l AG 08148 from the National Institute on Aging (Dr. Doty), and grant P0l DC 00161 from the National Institute on Deafness and Other Communication Disorders (Dr. Doty).

Received May 6, 1993. Accepted for publication in final form July 22, 1993.

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