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NEUROLOGY 1994;44:329
© 1994 American Academy of Neurology

A genetic marker and family history study of the upstate New York multiple sclerosis cluster

R. B. Schiffer, MD, Lowell R. Weitkamp, MD, Corey Ford, MD and W. Jackson Hall, PhD

Departments of Neurology, Psychiatry, and Environmental Medicine (Dr. Schiffer), The University of Rochester School of Medicine and Dentistry; the Departments of Genetics and Psychiatry (Dr. Weitkamp) and Statistics (Dr. Hall), University of Rochester, Rochester, NY; and the Department of Neurology (Dr. Ford), University of New Mexico, Albuquerque, NM.

We report nine additional cases of new-onset multiple sclerosis (MS) among employees of an upstate New York manufacturing plant that uses zinc as a primary metal. These cases, identified during the decade 1980 to 1989, had clinical onset of the disease between 1979 and 1987. The new cases confirm the increased incidence of MS previously reported in the plant population for the 1970 to 1979 decade. The MS subjects in this occupationally based cluster do not seem different from other MS patients with regard to rates of familial MS or the frequencies of alleles for human leukocyte (HLA-DR) antigens or transferrin. The frequency distribution of alleles for transferrin (an iron- and zinc-binding protein) may differ in these and other MS subjects compared with controls.

Address correspondence and reprint requests to Dr. R.B. Schiffer, Department of Neurology, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642.

Supported by research grant PP0051 from the National Multiple Sclerosis Society.

Received June 28, 1993. Accepted for publication in final form August 12, 1993.






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