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NEUROLOGY 1994;44:339
© 1994 American Academy of Neurology

ApoE {epsilon}4 allelic association with Alzheimer's disease

Independent confirmation using denaturing gradient gel electrophoresis

Michael L. Peacock, BS and John K. Fink, MD

Department of Neurology, University of Michigan, Ann Arbor, MI.

There is intriguing evidence associating apolipoprotein E (ApoE) with Alzheimer's disease (AD). ApoE is deposited with (3-amyloid in senile plaques and binds to (ß-amyloid in vitro. We used denaturing gradient gel electrophoresis to identify ApoE {epsilon}2, {epsilon}3, and {epsilon} 4 alleles in 135 control subjects and 57 AD patients. We observed a marked increase in ApoE {epsilon}4 allele frequency (0.40) in AD patients compared with control subjects (0.14) (p < 0.0001). Our independent finding of a marked association of ApoE t4 allele with AD further supports a possible role of ApoE in the pathogenesis of AD and confirms the study of Saunders et al (Neurology 1993;43:1467-1472).

Address correspondence and reprint requests to Dr. John K. Fink, Neuroscience Laboratory Building, 1103 E. Huron St., Ann Arbor, MI 48104-1687.

Supported by the grants from the NIH/NIA (1R01AG10691 01A1), Alzheimer's Disease and Related Disorders Association (FSA-92-018), the University of Michigan Geriatrics Research and Training Center, the Lucille P. Markey Charitable Trusts, and the Laboratory for Education and Research in Neuroscience.

Received September 7, 1993. Accepted for publication in final form October 27,1993.




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