NEUROLOGY 1994;44:499
© 1994 American Academy of Neurology
A clinical genetic study of Parkinson's disease
Evidence for dominant transmission
A. M. Lazzarini, MS,
R. H. Myers, PhD,
T. R. Zimmerman, Jr., MD,
M. H. Mark, MD,
L. I. Golbe, MD,
J. I. Sage, MD,
W. G. Johnson, MD and
R. C. Duvoisin, MD
Richard E. Heikkila APDA Advanced Center for Parkinson Research, Department of Neurology (A. M. Lazzarini and Drs. Zimmerman, Mark, Golbe, Sage, Johnson, and Duvoisin), University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ, and the Department of Neurology (Dr. Myers), Boston University School of Medicine, Boston, MA.
We used a family history questionnaire, semi-structured interview, and personal examination of secondary cases to collect data on the prevalence of Parkinson's disease (PD) in relatives of patients seen consecutively for 1 year and assessed the proportion of secondary cases of PD as a function of pedigree completeness. Survival analysis methods were applied to estimate the lifetime risk and age-at-onset distribution of PD among first-degree relatives of probands. When we considered siblings of probands with affected parents, the cumulative risk increased significantly over siblings of probands without affected parents, suggesting significant familial aggregation in a subset of randomly ascertained families. We further analyzed 80 multicase families with two or more affected individuals. Age-adjusted segregation ratios approaching 0.5 and similar proportions of affected parents and siblings, as well as the distribution of ancestral secondary cases, were compatible with an autosomal dominant mode of inheritance with reduced penetrance in a subset of PD
Address correspondence and reprint requests to Alice M. Lazzarini, MS, Department of Neurology, UMDNJ-Robert Wood Johnson Medical School, Room 118, 97 Paterson Street, New Brunswick, NJ 08903.
Supported by the William Dow Lovett Endowment and by the American Parkinson's Disease Association.
Presented in part at the 44th annual meeting of the American Academy of Neurology, San Diego, CA, May 1992
Received September 29, 1992. Accepted for publication in final form September 7, 1993.
This article has been cited by other articles:
|
|
|
|
 
J. Aharon-Peretz, H. Rosenbaum, and R. Gershoni-Baruch
Mutations in the Glucocerebrosidase Gene and Parkinson's Disease in Ashkenazi Jews
N. Engl. J. Med.,
November 4, 2004;
351(19):
1972 - 1977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Foltynie, S Sawcer, C Brayne, and R A Barker
The genetic basis of Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
October 1, 2002;
73(4):
363 - 370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Racette, M. Rundle, J. C. Wang, A. Goate, N. L. Saccone, M. Farrer, S. Lincoln, J. Hussey, S. Smemo, J. Lin, et al.
A multi-incident, Old-Order Amish family with PD
Neurology,
February 26, 2002;
58(4):
568 - 574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. V. Schapira
Neuroprotection and dopamine agonists
Neurology,
February 1, 2002;
58(90001):
S9 - 18.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N. E. Maher, L. I. Golbe, A. M. Lazzarini, M. H. Mark, L. J. Currie, G. F. Wooten, M. Saint-Hilaire, J. B. Wilk, J. Volcjak, J. E. Maher, et al.
Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
Neurology,
January 8, 2002;
58(1):
79 - 84.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Payami, N. Lee, S. Zareparsi, M. Gonzales McNeal, R. Camicioli, T.D. Bird, G. Sexton, S. Gancher, J. Kaye, D. Calhoun, et al.
Parkinson's disease, CYP2D6 polymorphism, and age
Neurology,
May 22, 2001;
56(10):
1363 - 1370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Dujardin, L. Defebvre, C. Grunberg, E. Becquet, and A. Destee
Memory and executive function in sporadic and familial Parkinson's disease
Brain,
February 1, 2001;
124(2):
389 - 398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M Autere, J. S Moilanen, V. V Myllyla, and K. Majamaa
Familial aggregation of Parkinson's disease in a Finnish population
J. Neurol. Neurosurg. Psychiatry,
July 1, 2000;
69(1):
107 - 109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Gouider-Khouja, S. Belal, M. B. Hamida, and F. Hentati
Clinical and genetic study of familial Parkinson's disease in Tunisia
Neurology,
April 25, 2000;
54(8):
1603 - 1609.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Dujardin, A. Duhamel, E. Becquet, C. Grunberg, L. Defebvre, and A. Destee
Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
September 1, 1999;
67(3):
323 - 328.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Vieregge, J. Hagenah, I. Heberlein, C. Klein, and H.-P. Ludin
Parkinson's disease in twins: A follow-up study
Neurology,
August 1, 1999;
53(3):
566 - 566.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P. Jarman and N. Wood
Parkinson's disease genetics comes of age
BMJ,
June 19, 1999;
318(7199):
1641 - 1642.
[Full Text]
|
|
|
|
|
|
|
A. Elbaz, F. Grigoletto, M. Baldereschi, M. M. Breteler, J. M. Manubens-Bertran, S. Lopez-Pousa, J. F. Dartigues, A. Alperovitch, C. Tzourio, and W. A. Rocca
Familial aggregation of Parkinson's disease: A population-based case-control study in Europe
Neurology,
June 1, 1999;
52(9):
1876 - 1876.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Papadimitriou, V. Veletza, G. M. Hadjigeorgiou, A. Patrikiou, M. Hirano, and I. Anastasopoulos
Mutated {alpha}-synuclein gene in two Greek kindreds with familial PD: Incomplete penetrance?
Neurology,
February 1, 1999;
52(3):
651 - 651.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
E. Munoz, V. Obach, R. Oliva, M. J. Marti, M. Ezquerra, P. Pastor, F. Ballesta, and E. Tolosa
{alpha}1-Antichymotrypsin gene polymorphism and susceptibility to Parkinson's disease
Neurology,
January 1, 1999;
52(2):
297 - 297.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. H. Polymeropoulos, C. Lavedan, E. Leroy, S. E. Ide, A. Dehejia, A. Dutra, B. Pike, H. Root, J. Rubenstein, R. Boyer, et al.
Mutation in the {alpha}-Synuclein Gene Identified in Families with Parkinson's Disease
Science,
June 27, 1997;
276(5321):
2045 - 2047.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Polymeropoulos, J. J. Higgins, L. I. Golbe, W. G. Johnson, S. E. Ide, G. Di Iorio, G. Sanges, E. S. Stenroos, L. T. Pho, A. A. Schaffer, et al.
Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23
Science,
November 15, 1996;
274(5290):
1197 - 1199.
[Abstract]
[Full Text]
|
|
|
|
