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NEUROLOGY 1994;44:609
© 1994 American Academy of Neurology

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery

K. A. Welsh, PhD, N. Butters, PhD, R. C. Mohs, PhD, D. Beekly, BS, S. Edland, MS, G. Fillenbaum, PhD and A. Heyman, MD

Duke University Medical Center, Durham, NC (Drs. Welsh, Fillenbanm, and Heyman)
Veterans Administration Medical Center and University of California at San Diego, La Jolla, CA (Dr. Butters)
Mount Sinai School of Medicine, New York, NY (Dr. Mohs)
University of Washington, Seattle, WA (D. Beekly and S. Edland).

The neuropsychological tests developed for the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) are currently used to measure cognitive impairments of Alzheimer's disease (AD) in clinical investigations of this disorder. This report presents the normative information for the CERAD battery, obtained in a large sample (n = 413) of control subjects (ages 50 to 89) who were enrolled in 23 university medical centers in the United States participating in the CERAD study from 1987 to 1992. We compared separately the performance of subjects with high (≥12) and low (<12) years of formal education. For many of the individual cognitive measures in the highly educated group, we observed significant age and gender effects. Only the praxis measure showed a significant age effect in the low-education group. Delayed recall, when adjusted for amount of material acquired (savings), was relatively unaffected by age, gender, and level of education. Our findings suggest that the savings scores, in particular, may be useful in distinguishing between AD and normal aging.

Address correspondence and reprint requests to Dr. Kathleen Welsh, Bryan Alzheimer's Disease Research Center, Duke University Medical Center, 2200 West Main Street, Suite A-230, Durham, NC 27705.

Supported by NIA grants AG06790 and AG05128 to Duke University Medical Center by funds from the Veterans Administration, Washington, DC, and NIA grants AG08024 and AG05131 to the University of California at San Diego, CA.

Received August 4, 1993. Accepted for publication in final form September 15, 1993.




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