| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Neurology, Boston University School of Medicine, Boston, MA (Drs. Farrer and Auerbach, and S. Blackburn and D.K. Kiely)
Epidemiology and Biostatistics, Boston University School of Medicine, Boston, MA (Drs. Farrer and Cupples)
Department of Neurology, Harvard Medical School, Boston, MA (Drs. Farrer and Growdon and L. Connor-Lacke)
Geriatric Psychiatry Service, The Queen Elizabeth Hospital, Toronto, ON, Canada (Dr. Karlinsky and A. Thibert)
Alzheimer's Disease Research Program, Riverview Hospital, Port Coquitlam, BC, Canada (Dr. Karlinsky)
Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC (Dr. Burke and C. Utley)
University of Southern California, Los Angeles, CA (Dr. Chui and A. Ireland)
Wien Center for Alzheimer's Disease and Memory Disorders, Mt. Sinai Medical Center, Miami Beach (Dr. Duara and R. Lopez-Alberola)
University of Miami School of Medicine, Miami, FL (Dr. Duara and R. Lopez-Alberola)
Departments of Medicine and Health Services, University of Washington, Seattle, WA (Dr. Larson and S. O'Connell)
Epidemiology, University of Washington, Seattle, WA (Dr. Kukull).
There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 ± 0.13) when the subjects were grouped as "AD" (probable or possible) versus "not AD," but somewhat lower (0.52 ± 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.
Address correspondence and reprint requests to Dr. Lindsay Farrer, Department of Neurology, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118.
Supported by National Institutes of Health grants R01-AGO9029 and P50-AG05134. L.A.F. is supported by a fellowship from the Alfred P. Sloan Foundation.
Received May 27, 1993. Accepted for publication in final form September 16, 1993.
This article has been cited by other articles:
|
|
 |
|
  D. H. Tsai, R. C. Green, K. S. Benke, R. A. Silliman, and L. A. Farrer Predictors of Subjective Memory Complaint in Cognitively Normal Relatives of Patients with Alzheimer's Disease J Neuropsychiatry Clin Neurosci, August 1, 2006; 18(3): 384 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Erlich, K. L. Lunetta, L. A. Cupples, M. Huyck, R. C. Green, C. T. Baldwin, L. A. Farrer, and for the MIRAGE Study Group Polymorphisms in the PON gene cluster are associated with Alzheimer disease Hum. Mol. Genet., January 1, 2006; 15(1): 77 - 85. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Roberts, L. A. Cupples, N. R. Relkin, P. J. Whitehouse, R. C. Green, and for the REVEAL (Risk Evaluation and Education for Genetic Risk Assessment for Adult Children of People With Alzheimer's Disease: The Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 250 - 255. [Abstract] [PDF]
|
|
|
|
 |
|
 R. C. Green, L. A. Cupples, A. Kurz, S. Auerbach, R. Go, D. Sadovnick, R. Duara, W. A. Kukull, H. Chui, T. Edeki, et al. Depression as a Risk Factor for Alzheimer Disease: The MIRAGE Study Arch Neurol, May 1, 2003; 60(5): 753 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Graff-Radford, R. C. Green, R. C. P. Go, M. L. Hutton, T. Edeki, D. Bachman, J. L. Adamson, P. Griffith, F. B. Willis, M. Williams, et al. Association Between Apolipoprotein E Genotype and Alzheimer Disease in African American Subjects Arch Neurol, April 1, 2002; 59(4): 594 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Green, L. A. Cupples, R. Go, K. S. Benke, T. Edeki, P. A. Griffith, M. Williams, Y. Hipps, N. Graff-Radford, D. Bachman, et al. Risk of Dementia Among White and African American Relatives of Patients With Alzheimer Disease JAMA, January 16, 2002; 287(3): 329 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Knopman, S. T. DeKosky, J. L. Cummings, H. Chui, J. Corey-Bloom, N. Relkin, G. W. Small, B. Miller, and J. C. Stevens Practice parameter: Diagnosis of dementia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology Neurology, May 8, 2001; 56(9): 1143 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, L. A. Cupples, A. Kurz, S. H. Auerbach, L. Volicer, H. Chui, R. C. Green, A. D. Sadovnick, R. Duara, C. DeCarli, et al. Head injury and the risk of AD in the MIRAGE study Neurology, March 28, 2000; 54(6): 1316 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Grundman Vitamin E and Alzheimer disease: the basis for additional clinical trials1 Am. J. Clinical Nutrition, February 1, 2000; 71(2): 630s - 636s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. L. Lopez, I. Litvan, K. E. Catt, R. Stowe, W. Klunk, D. I. Kaufer, J. T. Becker, and S. T. DeKosky Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias Neurology, October 1, 1999; 53(6): 1292 - 1292. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
