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NEUROLOGY 1994;44:666
© 1994 American Academy of Neurology

31P-Magnetic resonance spectroscopy in migraine without aura

P. Montagna, MD, P. Cortelli, MD, L. Monari, MD, G. Pierangeli, MD, P. Parchi, MD, R. Lodi, MD, S. Iotti, BSc, C. Frassineti, PhD, P. Zaniol, PhD, E. Lugaresi, MD and B. Barbiroli, MD

Institute of Neurology, Medical Pathology Institute "D. Campanacci," University of Bologna, Bologna (Drs. Montagna, Cortelli, Monari, Pierangeli, Parchi, and Lugaresi)
Department of Clinical Biochemistry, Medical Pathology Institute "D. Campanacci," University of Bologna, Bologna (Drs. Lodi and Barbiroli and S. Iotti)
Institutes of Biochemistry, University of Modena, Modena, Italy (Dr. Frassineti)
Radiology, University of Modena, Modena, Italy (Dr. Zaniol).

We investigated 22 patients with migraine without aura, all drug-free and in headache-free periods, by means of 31P-magnetic resonance spectroscopy (MRS) of brain and muscle. Brain 31P-MRS showed significantly low phosphocreatine, increased adenosine diphosphate, and decreased phosphorylation potential. There was a slow rate of phosphocreatine recovery after exercise in the muscle of 12 of 22 patients. Energy metabolism is abnormal in migraine without aura, as previously demonstrated in patients with migraine stroke and migraine with aura.

Address correspondence and reprint requests to Prof. Pasquale Montagna, Clinica Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy.

Presented in part at the 45th annual meeting of the American Academy of Neurology, New York, April 1993.

Received July 9, 1993. Accepted for publication in final form September 23, 1993.




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