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Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD. (Drs. Pascual-Leone, Valls-Solé, Brasil-Neto, Cammarota, and Hallett)
Human Motor Control Section, and the Cognitive Neuroscience Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD. (Dr. Grafman)
Article abstract –We studied the effects of repetitive transcranial stimulation of the motor cortex (rTMS) on choice reaction time (cRT), movement time (MT), and error rate (ER) in a serial reaction-time task in six medicated patients with Parkinson's disease (PD) and 10 age-matched normal controls. In normal subjects, subthreshold 5-Hz rTMS did not significantly change cRT, slightly shortened MT, but increased ER. In the patients, rTMS significantly shortened cRT and MT without affecting ER. These effects did not impair procedural learning. Performance on a grooved peg-board test was improved by rTMS in the same PD patients, especially when they were off medications, but worsened in the normal subjects. Repetitive, subthreshold motor cortex stimulation can improve performance in patients with PD and could be useful therapeutically.
Address correspondence and reprint requests to Dr. Mark Hallett, Building 10, Room 5N226, NINDS, NIH, Bethesda, MD 20892.
Received December 27, 1991. Accepted for publication in final form October 26, 1993.
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