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Clozapine treatment of spasmodic torticollis

Department of Psychiatry, University of Göttingen, Göttingen, Germany.

Article abstract We report a trial of clozapine (CLO) in patients with spasmodic torticollis (ST). In an open-design trial we treated five patients with adult-onset ST with CLO (300 mg/d) over 12 weeks and one patient over 3 weeks. We videotaped the patients three times (before and at the end of CLO treatment, and 2 weeks after CLO withdrawal) according to a standardized protocol. At the end of the treatment period, CLO plasma concentrations ranged from 67 to 371 ng/ml. In all six patients, analysis of the video ratings and patients' self-assessments failed to reveal any improvement of ST. These preliminary results fail to confirm any therapeutic benefit of CLO in the treatment of ST.

Address correspondence and reprint requests to Dr. Andreas Thiel, Department of Psychiatry, University of Göttingen, von-Siebold-Str. 5, 37075 Göttingen, Germany.

Received August 17, 1993. Accepted for publication in final form November 1, 1993.

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