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NEUROLOGY 1994;44:959
© 1994 American Academy of Neurology

Konzo in the Central African Republic

T. Tylleskär, MD, F. D. Légué, RN, S. Peterson, MD, MPH, E. Kpizingui, MD, MPH and P. Stecker, RN, MPH

International Child Health Unit, Uppsala University Hospital, Uppsala. Sweden (Drs. Tylleskär and Peterson)
Ministry of Public Health and Social Affairs, Bangui. Central African Republic (F. Légué and Dr. Kpizinguil)
Evangelical Lutheran Church in the Central African Republic Bouar. Central African Republic. (P.Stecker)

We identified a new focus of konzo, an upper motor neuron disease, in a part of western Central African Republic. Interviews and high serum levels of thiocyanate indicate that cyanide exposure from insufficiently processed cassava may cause konzo. Abrupt onset, nonprogressive course, and seronegativity to HTLV-I clearly differentiate konzo from HTLV-I-associated myelopathy in tropical countries.

Address correspondence and reprint requests to Dr. Thorkild Tylleskär. International Child Health. Uppsala University Hospital. S-751 85 Uppsala. Sweden.

Supported by t h e Swedish Agency for Research Cooperation with Developing Countries 1 (SAKEC): I and UNICEF-Bangui.

Received August 20, 1993. Accepted for publication in final form October 26, 1993






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