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NEUROLOGY 1994;44:967
© 1994 American Academy of Neurology

Progression of multifocal motor neuropathy during apparently successful treatment with human immunoglobulin

Jeffrey L. Elliott, MD and Alan Pestronk, MD

Department of Neurology, Washington University School of Medicine, St. Louis, MO.

Article abstract We report a patient with multifocal motor neuropathy (MMN) who experienced a paradoxical decline in baseline strength to below pretreatment levels during a period of improvement associated with human immunoglobulin (HIG) administration. This outcome suggests that HIG may not limit progression of MMN and may reduce the utility of HIG as chronic therapy.

Address correspondence and reprint requests to Dr. Alan Pestronk, Department of Neurology, Box 811 1, Washington University School of Medicine. 660 S. Euclid Avenue, St. Louis, MO 63110.

Received October 11, 1993. Accepted for publication i n final form November 9, 1993.




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