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NEUROLOGY 1994;44:1064
© 1994 American Academy of Neurology

Initial and follow-up brain MRI findings and correlation with the clinical course in Wilson's disease

J. K. Roh, MD, T. G. Lee, MD, B. A. Wie, MD, S. B. Lee, MD, S. H. Park, MD and K. H. Chang, MD

Departments of Neurology (Drs. Roh, T.G. Lee, Wie, and S.B. Lee) and Diagnostic Radiology (Dr. Chang), Seoul National University, College of Medicine, and the Department of Neurology (Dr. Park), Boramae City Hospital, Seoul, Republic of Korea.

We performed pretreatment brain MRIs in 25 patients with neurologically symptomatic Wilson's disease (WD) and clinical and MRI follow-up in 16 of them. All 25 pretreatment MRIs revealed abnormalities, with abnormal high-signal intensity (HSI) in bilateral thalami being the most common (92%). HSI lesions in the brainstem (84%) and the basal ganglia (72%) were also common. Brain atrophy was present in 88% of the 25 patients. In the follow-up period of 5 to 24 months, during which the patients were treated with D-penicillamine, both HSI lesions and neurologic symptoms improved in 88% of the 16 patients, but the brain atrophy did not change.

Address correspondence and reprint requests t o Dr. J.K. Roh, Department of Neurology, Seoul National University Hospital, 28, Yunkeun-dong, Chongno-ku, Seoul, 110-744, Republic of Korea.

Supported by a research fund from Seoul National University Hospital.

Received August 17, 1993. Accepted for publication in final form December 23, 1993.




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