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Departments of Neurology (Drs. Parker, Filley, and Cullum, and N.J. Mahr and J.K. Parks), Pediatrics (Dr. Parker), Preventive Medicine and Biometrics (Dr. Young), and Psychiatry (Drs. Filley and Cullum, and D. Hughes), University of Colorado School of Medicine, Denver, CO.
We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec–1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec–1/mg, p=0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.
Address correspondence and reprint requests to Dr. W.D. Parker, Box 394, University of Virginia Medical Center, Charlottesville, VA 22908.
Supported by grant AG09417 from the National Institute on Aging.
Received August 13, 1993. Accepted for publication in final form November 24, 1993.
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