HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Köller, H. Articles by Freund, H-J. Search for Related Content PubMed PubMed Citation Articles by Köller, H. Articles by Freund, H-J.

Deficiency of both protein C and protein S in a family with ischemic strokes in young adults

Departments of Neurology (Drs. Roller, Stoll, Sitzer, and Freund) and Internal Medicine-Haematology (Dr. Burk), and the Institute for Blood Coagulation and Transfusion Medicine (Dr. Schottler), Heinrich-Heine-University, Düsseldorf, Germany.

Protein C and protein S deficiencies increase the risk of venous thrombosis and pulmonary embolism, but their role in arterial thrombosis or embolism is controversial. We describe cerebral ischemia in two young women in a family with inherited deficiencies of both proteins C and S and provide evidence that a combined deficiency of proteins C and S may be a high risk factor for ischemic stroke in young adults.

Address correspondence and reprint requests to Dr. H. Köller, Department of Neurology, Heinrich-Heine-University, Moorenstraße 5, D 40225 Düsseldorf, Germany.

Received July 1, 1993. Accepted in final form January 14, 1994.

This article has been cited by other articles:

				D. Liu, H. Guo, J. H. Griffin, J. A. Fernandez, and B. V. Zlokovic Protein S Confers Neuronal Protection During Ischemic/Hypoxic Injury in Mice Circulation, April 8, 2003; 107(13): 1791 - 1796. [Abstract] [Full Text] [PDF]

				A. Hassan and H. S. Markus Genetics and ischaemic stroke Brain, September 1, 2000; 123(9): 1784 - 1812. [Abstract] [Full Text] [PDF]

				G. Kenet, J. Freedman, B. Shenkman, E. Regina, F. Brok-Simoni, F. Holzman, F. Vavva, N. Brand, A. Michelson, M. Trolliet, et al. Plasma Glutathione Peroxidase Deficiency and Platelet Insensitivity to Nitric Oxide in Children With Familial Stroke Arterioscler. Thromb. Vasc. Biol., August 1, 1999; 19(8): 2017 - 2023. [Abstract] [Full Text] [PDF]

				M. Margaglione, G. D'Andrea, N. Giuliani, V. Brancaccio, D. De Lucia, E. Grandone, V. De Stefano, P. A. Tonali, and G. Di Minno Inherited Prothrombotic Conditions and Premature Ischemic Stroke : Sex Difference in the Association With Factor V Leiden Arterioscler. Thromb. Vasc. Biol., July 1, 1999; 19(7): 1751 - 1756. [Abstract] [Full Text] [PDF]

				P. Lefebvre, B. Lierneux, L. Lenaerts, L. Van Maldergem, G. Marecaux, M. Daune, G. Bruninx, C. Delcour, and J.-C. Wautrecht Cerebral Venous Thrombosis and Procoagulant Factors: A Case Study Angiology, July 1, 1998; 49(7): 563 - 571. [Abstract] [PDF]

				H. S Markus and H. Hambley Neurology and the blood: haematological abnormalities in ischaemic stroke J. Neurol. Neurosurg. Psychiatry, February 1, 1998; 64(2): 150 - 159. [Full Text] [PDF]

				P. Robbins, M. Forrest, and D. Royston Hypercoagulable States Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 1997; 1(4): 295 - 318. [Abstract] [PDF]

				P. Ferraresi, G. Marchetti, C. Legnani, E. Cavallari, E. Castoldi, F. Mascoli, D. Ardissino, G. Palareti, and F. Bernardi The Heterozygous 20210 G/A Prothrombin Genotype Is Associated With Early Venous Thrombosis in Inherited Thrombophilias and Is Not Increased in Frequency in Artery Disease Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2418 - 2422. [Abstract] [Full Text]